Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic liver diseases, including advanced stages o...

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Bibliographic Details
Main Authors: Ece Yildiz, Gaby El Alam, Alessia Perino, Antoine Jalil, Pierre-Damien Denechaud, Katharina Huber, Lluis Fajas, Johan Auwerx, Giovanni Sorrentino, Kristina Schoonjans
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
BECs
liver steatosis
BEC-organoids
BEC activation
cell cycle
glycolysis
Online Access:https://elifesciences.org/articles/81926

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