Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration
Synthetic bone grafts are in high demand owing to increased age-related bone disorders in the global aging population. Here, we report fabrication of gear-shaped granules (G-GRNs) for rapid bone healing. G-GRNs possessed six protrusions and a hexagonal macropore in the granular center. These were co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023001514 |
| _version_ | 1797384089681002496 |
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| author | Koichiro Hayashi Toshiki Yanagisawa Ryo Kishida Akira Tsuchiya Kunio Ishikawa |
| author_facet | Koichiro Hayashi Toshiki Yanagisawa Ryo Kishida Akira Tsuchiya Kunio Ishikawa |
| author_sort | Koichiro Hayashi |
| collection | DOAJ |
| description | Synthetic bone grafts are in high demand owing to increased age-related bone disorders in the global aging population. Here, we report fabrication of gear-shaped granules (G-GRNs) for rapid bone healing. G-GRNs possessed six protrusions and a hexagonal macropore in the granular center. These were composed of carbonate apatite, i.e., bone mineral, microspheres with ∼1-μm micropores in the spaces between the microspheres. G-GRNs formed new bone and blood vessels (both on the granular surface and within the macropores) 4 weeks after implantation in the rabbit femur defects. The formed bone structure was similar to that of cancellous bone. The bone percentage in the defect recovered to that in a normal rabbit femur at week-4 post-implantation, and the bone percentage remained constant for the following 8 weeks. Throughout the entire period, the bone percentage in the G-GRN-implanted group was ∼10% higher than that of the group implanted with conventional carbonate apatite granules. Furthermore, a portion of the G-GRNs resorbed at week-4, and resorption continued for the following 8 weeks. Thus, G-GRNs are involved in bone remodeling and are gradually replaced with new bone while maintaining a suitable bone level. These findings provide a basis for the design and fabrication of synthetic bone grafts for achieving rapid bone regeneration. |
| first_indexed | 2024-03-08T21:31:35Z |
| format | Article |
| id | doaj.art-bf976ffe1ba348728b4e8ddc6fbf7c33 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:31:35Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-bf976ffe1ba348728b4e8ddc6fbf7c332023-12-21T07:31:22ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012125142523Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regenerationKoichiro Hayashi0Toshiki Yanagisawa1Ryo Kishida2Akira Tsuchiya3Kunio Ishikawa4Corresponding author.; Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3–1-1 Maidashi Higashi-ku, Fukuoka 812–8582, JapanDepartment of Biomaterials, Faculty of Dental Science, Kyushu University, 3–1-1 Maidashi Higashi-ku, Fukuoka 812–8582, JapanDepartment of Biomaterials, Faculty of Dental Science, Kyushu University, 3–1-1 Maidashi Higashi-ku, Fukuoka 812–8582, JapanDepartment of Biomaterials, Faculty of Dental Science, Kyushu University, 3–1-1 Maidashi Higashi-ku, Fukuoka 812–8582, JapanDepartment of Biomaterials, Faculty of Dental Science, Kyushu University, 3–1-1 Maidashi Higashi-ku, Fukuoka 812–8582, JapanSynthetic bone grafts are in high demand owing to increased age-related bone disorders in the global aging population. Here, we report fabrication of gear-shaped granules (G-GRNs) for rapid bone healing. G-GRNs possessed six protrusions and a hexagonal macropore in the granular center. These were composed of carbonate apatite, i.e., bone mineral, microspheres with ∼1-μm micropores in the spaces between the microspheres. G-GRNs formed new bone and blood vessels (both on the granular surface and within the macropores) 4 weeks after implantation in the rabbit femur defects. The formed bone structure was similar to that of cancellous bone. The bone percentage in the defect recovered to that in a normal rabbit femur at week-4 post-implantation, and the bone percentage remained constant for the following 8 weeks. Throughout the entire period, the bone percentage in the G-GRN-implanted group was ∼10% higher than that of the group implanted with conventional carbonate apatite granules. Furthermore, a portion of the G-GRNs resorbed at week-4, and resorption continued for the following 8 weeks. Thus, G-GRNs are involved in bone remodeling and are gradually replaced with new bone while maintaining a suitable bone level. These findings provide a basis for the design and fabrication of synthetic bone grafts for achieving rapid bone regeneration.http://www.sciencedirect.com/science/article/pii/S2001037023001514GranulesBoneGraftsCalcium phosphateScaffoldBio ceramics |
| spellingShingle | Koichiro Hayashi Toshiki Yanagisawa Ryo Kishida Akira Tsuchiya Kunio Ishikawa Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration Computational and Structural Biotechnology Journal Granules Bone Grafts Calcium phosphate Scaffold Bio ceramics |
| title | Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration |
| title_full | Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration |
| title_fullStr | Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration |
| title_full_unstemmed | Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration |
| title_short | Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration |
| title_sort | gear shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration |
| topic | Granules Bone Grafts Calcium phosphate Scaffold Bio ceramics |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023001514 |
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