Is There a Two-Way Risk between Decreased Testosterone Levels and the Progression and Prognosis of Chronic Kidney Disease? A Cohort Study Based on the National Health and Nutrition Examination Survey Database
Purpose: The causal relationship between the incidence and prognosis of chronic kidney disease (CKD) and serum testosterone levels in patients is not yet fully understood. This study aims to use the National Health and Nutrition Examination Survey (NHANES), a large-scale nationally representative...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2024-04-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| Summary: | Purpose: The causal relationship between the incidence and prognosis of chronic kidney disease (CKD) and serum testosterone
levels in patients is not yet fully understood. This study aims to use the National Health and Nutrition Examination Survey
(NHANES), a large-scale nationally representative sample, to investigate the relationship between CKD and testosterone.
Materials and Methods: This study included six NHANES cycles for linear regression analysis, verified by multiple imputation
methods. Stratified analysis and subgroup analysis were used to demonstrate the stability of CKD’s effect on testosterone. Furthermore,
we used Kaplan-Meier plots and log-rank tests to evaluate differences in survival rates between CKD male patients
with low and normal levels of testosterone.
Results: From a total of 71,163 subjects, the cohort selected 28,663 eligible participants. Results showed that CKD patients
had testosterone levels 28.423 ng/mL (24.762, 32.083) lower than non-CKD patients. The results of multiple imputations
(β=27.700, 95% confidence interval: 23.427, 31.974) were consistent with those of linear regression analysis, and the numerical
match was good. Stratified regression analysis, and subgroup analysis results showed that CKD had a significant
impact on testosterone at different dimensions. Kaplan-Meier plots showed significantly reduced survival rates in low testosterone
CKD male patients (p<0.0001).
Conclusions: The results of this big data analysis suggest that there may be a two-way risk between low levels of testosterone
and CKD. The testosterone levels of CKD patients were significantly lower than those of the non-CKD population, and CKD
patients with low testosterone levels had poorer prognoses. These results suggest that correcting testosterone levels in a timely
manner can have preventive and therapeutic effects on the progression of CKD. |
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| ISSN: | 2287-4208 2287-4690 |