A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets
Orally disintegrating tablets (ODTs) comprising sustained release (SR) coated microparticles smaller than 250 µm provide an appealing dosage form for patients with dysphagia, offering a superior mouthfeel and highly convenient route of administration without the need for water. SR coating for microp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2022-11-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/1142/ |
| _version_ | 1797825339619016704 |
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| author | Kavil Patel Darragh Murnane Craig Richardson Fang Liu |
| author_facet | Kavil Patel Darragh Murnane Craig Richardson Fang Liu |
| author_sort | Kavil Patel |
| collection | DOAJ |
| description | Orally disintegrating tablets (ODTs) comprising sustained release (SR) coated microparticles smaller than 250 µm provide an appealing dosage form for patients with dysphagia, offering a superior mouthfeel and highly convenient route of administration without the need for water. SR coating for microparticles of the requisite size(<200 µm) is incredibly challenging however the utilisation of the MicroCoat™ technology, whereby various dry powder glidants are added during SR coating, was demonstrated to achieve desirable coating outcomes. ODTs were prepared via direct compression. In addition to conventional USP methods, texture analysis(TA) was applied to determine disintegration. ODTs were shown to disintegrate within an acceptable time (<30s) and drug release was unaffected by compression during tabletting indicating a robust coating. |
| first_indexed | 2024-03-13T10:52:38Z |
| format | Article |
| id | doaj.art-bf978058a4f44323b6347bc7bf55d2b6 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T10:52:38Z |
| publishDate | 2022-11-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-bf978058a4f44323b6347bc7bf55d2b62023-05-17T10:29:24ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562022-11-017210.5920/bjpharm.1142A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating TabletsKavil Patel0Darragh Murnane1Craig Richardson2Fang Liu3University of HertfordshireUniversity of HertfordshireIP Group PLCUniversity of HertfordshireOrally disintegrating tablets (ODTs) comprising sustained release (SR) coated microparticles smaller than 250 µm provide an appealing dosage form for patients with dysphagia, offering a superior mouthfeel and highly convenient route of administration without the need for water. SR coating for microparticles of the requisite size(<200 µm) is incredibly challenging however the utilisation of the MicroCoat™ technology, whereby various dry powder glidants are added during SR coating, was demonstrated to achieve desirable coating outcomes. ODTs were prepared via direct compression. In addition to conventional USP methods, texture analysis(TA) was applied to determine disintegration. ODTs were shown to disintegrate within an acceptable time (<30s) and drug release was unaffected by compression during tabletting indicating a robust coating.https://www.bjpharm.org.uk/article/id/1142/sustained release; microparticlescoatingdysphagiasustained releasemicroparticles |
| spellingShingle | Kavil Patel Darragh Murnane Craig Richardson Fang Liu A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets British Journal of Pharmacy sustained release; microparticles coating dysphagia sustained release microparticles |
| title | A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets |
| title_full | A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets |
| title_fullStr | A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets |
| title_full_unstemmed | A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets |
| title_short | A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets |
| title_sort | translation of technology microcoat™ to sustained release orally disintegrating tablets |
| topic | sustained release; microparticles coating dysphagia sustained release microparticles |
| url | https://www.bjpharm.org.uk/article/id/1142/ |
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