Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia
<p>Objective. The study was designed to assess the morphology and structural changes in the walls of the left subclavian artery in neonates and infants with coarctation and aortic arch hypoplasia.<br />Methods. The study included 27 patients with hypoplasia of the aortic arch at the age...
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| Language: | English |
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Meshalkin National Medical Research Center
2016-01-01
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| Series: | Патология кровообращения и кардиохирургия |
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| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/260 |
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| author | И. А. Сойнов Ю. С. Синельников Е. Э. Кливер И. А. Корнилов Н. Р. Ничай А. В. Горбатых Ю. Ю. Кулябин Ю. Н. Горбатых |
| author_facet | И. А. Сойнов Ю. С. Синельников Е. Э. Кливер И. А. Корнилов Н. Р. Ничай А. В. Горбатых Ю. Ю. Кулябин Ю. Н. Горбатых |
| author_sort | И. А. Сойнов |
| collection | DOAJ |
| description | <p>Objective. The study was designed to assess the morphology and structural changes in the walls of the left subclavian artery in neonates and infants with coarctation and aortic arch hypoplasia.<br />Methods. The study included 27 patients with hypoplasia of the aortic arch at the age of 64 (27; 89) days, average body weight of 3.6±1.1 (from 1.8 to 6.9 kg), who were operated at the Center of Pediatric Surgery of Academician Ye. Meshalkin Research Institute of Circulation Pathology in the period from 2013 to 2014. All patients underwent off-pump surgery of hypoplasia of the aortic arch by using modified reverse plasty with a patch from the left subclavian artery. The patch was taken intraoperatively to determine the ratio of elastin and collagen. The results were compared with those of the control group.<br />Results. Significant differences were found in the content of collagen and elastic fibers in patients with aortic arch hypoplasia. Patients with hypoplasia had a significantly higher content of thin collagen and a lower content of elastic fibers in the wall of the subclavian artery.<br />Conclusion. The morphology of the subclavian artery in children with aortic arch hypoplasia is characterized by an increase of collagen and a decrease of elastic fibers due to the proliferation of smooth muscle cells, myofibroblasts, fibroblasts and the change in their relationship. These features determine the changes in elastic characteristics of the vascular wall, i.e. increased rigidity.</p> |
| first_indexed | 2024-03-12T08:41:05Z |
| format | Article |
| id | doaj.art-bf97d86a66b845769a3a6ac9ccb2e830 |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T08:41:05Z |
| publishDate | 2016-01-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-bf97d86a66b845769a3a6ac9ccb2e8302023-09-02T16:49:16ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192016-01-01194141810.21688/1681-3472-2015-4-14-18972Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasiaИ. А. Сойнов0Ю. С. Синельников1Е. Э. Кливер2И. А. Корнилов3Н. Р. Ничай4А. В. Горбатых5Ю. Ю. Кулябин6Ю. Н. Горбатых7Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Федеральный центр сердечно-сосудистой хирургии Министерства здравоохранения Российской Федерации, 614013, Пермь, ул. Маршала Жукова, 35Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15<p>Objective. The study was designed to assess the morphology and structural changes in the walls of the left subclavian artery in neonates and infants with coarctation and aortic arch hypoplasia.<br />Methods. The study included 27 patients with hypoplasia of the aortic arch at the age of 64 (27; 89) days, average body weight of 3.6±1.1 (from 1.8 to 6.9 kg), who were operated at the Center of Pediatric Surgery of Academician Ye. Meshalkin Research Institute of Circulation Pathology in the period from 2013 to 2014. All patients underwent off-pump surgery of hypoplasia of the aortic arch by using modified reverse plasty with a patch from the left subclavian artery. The patch was taken intraoperatively to determine the ratio of elastin and collagen. The results were compared with those of the control group.<br />Results. Significant differences were found in the content of collagen and elastic fibers in patients with aortic arch hypoplasia. Patients with hypoplasia had a significantly higher content of thin collagen and a lower content of elastic fibers in the wall of the subclavian artery.<br />Conclusion. The morphology of the subclavian artery in children with aortic arch hypoplasia is characterized by an increase of collagen and a decrease of elastic fibers due to the proliferation of smooth muscle cells, myofibroblasts, fibroblasts and the change in their relationship. These features determine the changes in elastic characteristics of the vascular wall, i.e. increased rigidity.</p>http://journalmeshalkin.ru/index.php/heartjournal/article/view/260Гипоплазия дуги аортыМорфологияЭластичность |
| spellingShingle | И. А. Сойнов Ю. С. Синельников Е. Э. Кливер И. А. Корнилов Н. Р. Ничай А. В. Горбатых Ю. Ю. Кулябин Ю. Н. Горбатых Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia Патология кровообращения и кардиохирургия Гипоплазия дуги аорты Морфология Эластичность |
| title | Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia |
| title_full | Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia |
| title_fullStr | Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia |
| title_full_unstemmed | Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia |
| title_short | Morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia |
| title_sort | morphological features of brachiocephalic arteries in patients with aortic arch hypoplasia |
| topic | Гипоплазия дуги аорты Морфология Эластичность |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/260 |
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