Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence
Compared with hyperpolarized noble gas MRI, oxygen-enhanced lung imaging is a cost-effective approach to investigate lung function. In this study, we investigated the feasibility of free-breathing phase-resolved oxygen-enhanced pulmonary MRI based on a 3D stack-of-stars ultra-short echo time (UTE) s...
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MDPI AG
2022-04-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/22/9/3270 |
| _version_ | 1797502869525495808 |
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| author | Pengfei Xu Jichang Zhang Zhen Nan Thomas Meersmann Chengbo Wang |
| author_facet | Pengfei Xu Jichang Zhang Zhen Nan Thomas Meersmann Chengbo Wang |
| author_sort | Pengfei Xu |
| collection | DOAJ |
| description | Compared with hyperpolarized noble gas MRI, oxygen-enhanced lung imaging is a cost-effective approach to investigate lung function. In this study, we investigated the feasibility of free-breathing phase-resolved oxygen-enhanced pulmonary MRI based on a 3D stack-of-stars ultra-short echo time (UTE) sequence. We conducted both computer simulation and in vivo experiments and calculated percent signal enhancement maps of four different respiratory phases on four healthy volunteers from the end of expiration to the end of inspiration. The phantom experiment was implemented to verify simulation results. The respiratory phase was segmented based on the extracted respiratory signal and sliding window reconstruction, providing phase-resolved pulmonary MRI. Demons registration algorithm was applied to compensate for respiratory motion. The mean percent signal enhancement of the average phase increases from anterior to posterior region, matching previous literature. More details of pulmonary tissues were observed on post-oxygen inhalation images through the phase-resolved technique. Phase-resolved UTE pulmonary MRI shows the potential as a valuable method for oxygen-enhanced MRI that enables the investigation of lung ventilation on middle states of the respiratory cycle. |
| first_indexed | 2024-03-10T03:42:18Z |
| format | Article |
| id | doaj.art-bf9888d508f5413882ce69ade963f058 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T03:42:18Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-bf9888d508f5413882ce69ade963f0582023-11-23T09:15:58ZengMDPI AGSensors1424-82202022-04-01229327010.3390/s22093270Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE SequencePengfei Xu0Jichang Zhang1Zhen Nan2Thomas Meersmann3Chengbo Wang4Electrical and Electronic Engineering, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo 315100, ChinaElectrical and Electronic Engineering, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo 315100, ChinaElectrical and Electronic Engineering, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo 315100, ChinaSir Peter Mansfield Magnetic Imaging Center, University of Nottingham, Nottingham NG7 2RD, UKElectrical and Electronic Engineering, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo 315100, ChinaCompared with hyperpolarized noble gas MRI, oxygen-enhanced lung imaging is a cost-effective approach to investigate lung function. In this study, we investigated the feasibility of free-breathing phase-resolved oxygen-enhanced pulmonary MRI based on a 3D stack-of-stars ultra-short echo time (UTE) sequence. We conducted both computer simulation and in vivo experiments and calculated percent signal enhancement maps of four different respiratory phases on four healthy volunteers from the end of expiration to the end of inspiration. The phantom experiment was implemented to verify simulation results. The respiratory phase was segmented based on the extracted respiratory signal and sliding window reconstruction, providing phase-resolved pulmonary MRI. Demons registration algorithm was applied to compensate for respiratory motion. The mean percent signal enhancement of the average phase increases from anterior to posterior region, matching previous literature. More details of pulmonary tissues were observed on post-oxygen inhalation images through the phase-resolved technique. Phase-resolved UTE pulmonary MRI shows the potential as a valuable method for oxygen-enhanced MRI that enables the investigation of lung ventilation on middle states of the respiratory cycle.https://www.mdpi.com/1424-8220/22/9/3270oxygen-enhanced lung MRIphase resolvefree-breathingUTE sequencestack-of-stars |
| spellingShingle | Pengfei Xu Jichang Zhang Zhen Nan Thomas Meersmann Chengbo Wang Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence Sensors oxygen-enhanced lung MRI phase resolve free-breathing UTE sequence stack-of-stars |
| title | Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence |
| title_full | Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence |
| title_fullStr | Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence |
| title_full_unstemmed | Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence |
| title_short | Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence |
| title_sort | free breathing phase resolved oxygen enhanced pulmonary mri based on 3d stack of stars ute sequence |
| topic | oxygen-enhanced lung MRI phase resolve free-breathing UTE sequence stack-of-stars |
| url | https://www.mdpi.com/1424-8220/22/9/3270 |
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