Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
Abstract The onset and worsening of some diseases are related to the variation and instability of gut microbiota. However, studies examining the personal variation of gut microbiota in detail are limited. Here, we evaluated the yearly variation of individual gut microbiota in 218 Japanese subjects a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-91917-6 |
| _version_ | 1818400487045595136 |
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| author | Ryuta Amamoto Kazuhito Shimamoto Sungjin Park Hoshitaka Matsumoto Kensuke Shimizu Miyuki Katto Hirokazu Tsuji Satoshi Matsubara Roy J. Shephard Yukitoshi Aoyagi |
| author_facet | Ryuta Amamoto Kazuhito Shimamoto Sungjin Park Hoshitaka Matsumoto Kensuke Shimizu Miyuki Katto Hirokazu Tsuji Satoshi Matsubara Roy J. Shephard Yukitoshi Aoyagi |
| author_sort | Ryuta Amamoto |
| collection | DOAJ |
| description | Abstract The onset and worsening of some diseases are related to the variation and instability of gut microbiota. However, studies examining the personal variation of gut microbiota in detail are limited. Here, we evaluated the yearly variation of individual gut microbiota in 218 Japanese subjects aged 66–91 years, using Jensen-Shannon distance (JSD) metrics. Approximately 9% of the subjects showed a substantial change, as their formerly predominant bacterial families were replaced over the year. These subjects consumed fermented milk products less frequently than their peers. The relationship between the intake frequencies of fermented milk products containing Lactocaseibacillus paracasei strain Shirota (LcS) and JSD values was also investigated. The intra-individual JSD of subjects ingesting LcS products ≥ 3 days/week over the past 10 years was statistically lower than the < 3 days/week group (P = 0.045). Focusing on subjects with substantial gut microbiota changes, only 1.7% of the subjects were included in the LcS intake ≥ 3 days/week group whereas 11.3% were found in the < 3 days/week group (P = 0.029). These results suggest that about one-tenth of the elderly Japanese could experience a substantial change in their gut microbiota during a 1-year period, and that the habitual intake of probiotics may stabilize their gut microbiota. |
| first_indexed | 2024-12-14T07:37:21Z |
| format | Article |
| id | doaj.art-bf9897d54aab4541967a5a4250422a35 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:37:21Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bf9897d54aab4541967a5a4250422a352022-12-21T23:11:08ZengNature PortfolioScientific Reports2045-23222021-06-0111111410.1038/s41598-021-91917-6Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changesRyuta Amamoto0Kazuhito Shimamoto1Sungjin Park2Hoshitaka Matsumoto3Kensuke Shimizu4Miyuki Katto5Hirokazu Tsuji6Satoshi Matsubara7Roy J. Shephard8Yukitoshi Aoyagi9Food Research Department, Yakult Central InstituteFood Research Department, Yakult Central InstituteExercise Sciences Research Group, Tokyo Metropolitan Institute of GerontologyMicrobiological Research Department, Yakult Central InstituteMicrobiological Research Department, Yakult Central InstituteMicrobiological Research Department, Yakult Central InstituteBasic Research Department, Yakult Central InstituteFood Research Department, Yakult Central InstituteFaculty of Kinesiology and Physical Education, University of TorontoExercise Sciences Research Group, Tokyo Metropolitan Institute of GerontologyAbstract The onset and worsening of some diseases are related to the variation and instability of gut microbiota. However, studies examining the personal variation of gut microbiota in detail are limited. Here, we evaluated the yearly variation of individual gut microbiota in 218 Japanese subjects aged 66–91 years, using Jensen-Shannon distance (JSD) metrics. Approximately 9% of the subjects showed a substantial change, as their formerly predominant bacterial families were replaced over the year. These subjects consumed fermented milk products less frequently than their peers. The relationship between the intake frequencies of fermented milk products containing Lactocaseibacillus paracasei strain Shirota (LcS) and JSD values was also investigated. The intra-individual JSD of subjects ingesting LcS products ≥ 3 days/week over the past 10 years was statistically lower than the < 3 days/week group (P = 0.045). Focusing on subjects with substantial gut microbiota changes, only 1.7% of the subjects were included in the LcS intake ≥ 3 days/week group whereas 11.3% were found in the < 3 days/week group (P = 0.029). These results suggest that about one-tenth of the elderly Japanese could experience a substantial change in their gut microbiota during a 1-year period, and that the habitual intake of probiotics may stabilize their gut microbiota.https://doi.org/10.1038/s41598-021-91917-6 |
| spellingShingle | Ryuta Amamoto Kazuhito Shimamoto Sungjin Park Hoshitaka Matsumoto Kensuke Shimizu Miyuki Katto Hirokazu Tsuji Satoshi Matsubara Roy J. Shephard Yukitoshi Aoyagi Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes Scientific Reports |
| title | Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes |
| title_full | Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes |
| title_fullStr | Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes |
| title_full_unstemmed | Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes |
| title_short | Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes |
| title_sort | yearly changes in the composition of gut microbiota in the elderly and the effect of lactobacilli intake on these changes |
| url | https://doi.org/10.1038/s41598-021-91917-6 |
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