Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis

Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis

Most advanced non-small cell lung cancer (NSCLC) patients are accompanied by brain metastasis which is the major cause of increased mortality. The fusion rearrangement of anaplastic lymphoma kinase (ALK) gene is an important feature of brain metastasis in lung cancer. The novel ALK inhibitors alect...

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Bibliographic Details
Main Authors: Xu Feng, En-Shi Xu
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021-06-01
Series:Biomolecules & Biomedicine
Subjects:
ALK
alectinib
lorlatinib
VIM
FN1
MMPs
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/5066

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