The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential
Neuropathic pain (NP) is a common chronic pain condition resulted from lesions or diseases of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of evidence supports the relationship between pathogenesis and N6-methyladenosine (m6A) modifications of RNA. However, stud...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223011964 |
| _version_ | 1797686887087865856 |
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| author | Liping Wu Hongliang Tang |
| author_facet | Liping Wu Hongliang Tang |
| author_sort | Liping Wu |
| collection | DOAJ |
| description | Neuropathic pain (NP) is a common chronic pain condition resulted from lesions or diseases of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of evidence supports the relationship between pathogenesis and N6-methyladenosine (m6A) modifications of RNA. However, studies on the role of m6A modifications in NP are still at an early stage. Elucidating different etiologies is important for understanding the specific pathogenesis of NP. This article provides a comprehensive review on the role of m6A methylation modifications including methyltransferases (''writers''), demethylases (''erasers''), and m6A binding proteins (''readers'') in NP models. Further analysis of the pathogenic mechanism relationship between m6A and NP provided novel theoretical and practical significance for clinical treatment of NP. |
| first_indexed | 2024-03-12T01:11:05Z |
| format | Article |
| id | doaj.art-bf997a2352194ef2a50a2712abdda3dc |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:11:05Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-bf997a2352194ef2a50a2712abdda3dc2023-09-14T04:52:54ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115398The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potentialLiping Wu0Hongliang Tang1Guangxi University of Traditional Chinese Medicine, Nanning, China; The First Clinical Medical College of Guangxi University of Traditional Chinese Medicine, Nanning, ChinaGuangxi Traditional Chinese Medicine University Affiliated Fangchenggang Hospital; Corresponding author.Neuropathic pain (NP) is a common chronic pain condition resulted from lesions or diseases of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of evidence supports the relationship between pathogenesis and N6-methyladenosine (m6A) modifications of RNA. However, studies on the role of m6A modifications in NP are still at an early stage. Elucidating different etiologies is important for understanding the specific pathogenesis of NP. This article provides a comprehensive review on the role of m6A methylation modifications including methyltransferases (''writers''), demethylases (''erasers''), and m6A binding proteins (''readers'') in NP models. Further analysis of the pathogenic mechanism relationship between m6A and NP provided novel theoretical and practical significance for clinical treatment of NP.http://www.sciencedirect.com/science/article/pii/S0753332223011964M6A methylation modificationNeuropathic painRodent modelMechanism of actionTargeted therapy |
| spellingShingle | Liping Wu Hongliang Tang The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential Biomedicine & Pharmacotherapy M6A methylation modification Neuropathic pain Rodent model Mechanism of action Targeted therapy |
| title | The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential |
| title_full | The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential |
| title_fullStr | The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential |
| title_full_unstemmed | The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential |
| title_short | The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential |
| title_sort | role of n6 methyladenosine modification in rodent models of neuropathic pain from the mechanism to therapeutic potential |
| topic | M6A methylation modification Neuropathic pain Rodent model Mechanism of action Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223011964 |
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