1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study
Efforts are currently being directed to identify a non-invasive marker that can serve as a solid and clinically irrefutable diagnostic criterion for histamine intolerance associated with diamine oxidase (DAO) deficiency. Accordingly, the identification of biomarkers of histamine (HA) metabolism in u...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.973682/full |
| _version_ | 1828105949498310656 |
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| author | Sònia Sánchez-Pérez Sònia Sánchez-Pérez Sònia Sánchez-Pérez Ricard Celorio-Sardà Ricard Celorio-Sardà Ricard Celorio-Sardà M. Teresa Veciana-Nogués M. Teresa Veciana-Nogués M. Teresa Veciana-Nogués M. Luz Latorre-Moratalla M. Luz Latorre-Moratalla M. Luz Latorre-Moratalla Oriol Comas-Basté Oriol Comas-Basté Oriol Comas-Basté M. Carmen Vidal-Carou M. Carmen Vidal-Carou M. Carmen Vidal-Carou |
| author_facet | Sònia Sánchez-Pérez Sònia Sánchez-Pérez Sònia Sánchez-Pérez Ricard Celorio-Sardà Ricard Celorio-Sardà Ricard Celorio-Sardà M. Teresa Veciana-Nogués M. Teresa Veciana-Nogués M. Teresa Veciana-Nogués M. Luz Latorre-Moratalla M. Luz Latorre-Moratalla M. Luz Latorre-Moratalla Oriol Comas-Basté Oriol Comas-Basté Oriol Comas-Basté M. Carmen Vidal-Carou M. Carmen Vidal-Carou M. Carmen Vidal-Carou |
| author_sort | Sònia Sánchez-Pérez |
| collection | DOAJ |
| description | Efforts are currently being directed to identify a non-invasive marker that can serve as a solid and clinically irrefutable diagnostic criterion for histamine intolerance associated with diamine oxidase (DAO) deficiency. Accordingly, the identification of biomarkers of histamine (HA) metabolism in urine is proposed as a possible new diagnostic strategy. It is hypothesized that individuals with histamine intolerance could have a different urinary profile of HA and its metabolites in comparison with the healthy population. Thus, the aim of this study was to assess the urinary excretion of HA and 1-methylhistamine (MHA) in individuals diagnosed with histamine intolerance and in a control group. Levels of HA and MHA were compared between 24 h and first morning spot urine in a subgroup of 14 control individuals. Then, HA and MHA concentrations in spot urine of 32 histamine intolerant and 55 control individuals were determined by ultra-high performance liquid chromatography and fluorometric detection (UHPLC-FL) and normalized by creatinine. No differences were found between HA and MHA levels in 24 h and first morning samples. Overall, histamine intolerant patients presented a distinct urinary excretion profile compared to the control group due to lower levels of MHA. No differences in urinary MHA were observed related to serum DAO activity. Spot urine samples were thus validated as a reliable tool to determine the urinary excretion of HA and MHA. These results constitute a starting point for the study of HA metabolomics as a suitable and non-invasive approach to histamine intolerance diagnosis. |
| first_indexed | 2024-04-11T10:09:56Z |
| format | Article |
| id | doaj.art-bf99db63892d4e6b8a86c5ece244d3c5 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T10:09:56Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-bf99db63892d4e6b8a86c5ece244d3c52022-12-22T04:30:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.9736829736821-methylhistamine as a potential biomarker of food histamine intolerance. A pilot studySònia Sánchez-Pérez0Sònia Sánchez-Pérez1Sònia Sánchez-Pérez2Ricard Celorio-Sardà3Ricard Celorio-Sardà4Ricard Celorio-Sardà5M. Teresa Veciana-Nogués6M. Teresa Veciana-Nogués7M. Teresa Veciana-Nogués8M. Luz Latorre-Moratalla9M. Luz Latorre-Moratalla10M. Luz Latorre-Moratalla11Oriol Comas-Basté12Oriol Comas-Basté13Oriol Comas-Basté14M. Carmen Vidal-Carou15M. Carmen Vidal-Carou16M. Carmen Vidal-Carou17Departament de Nutrició, Ciències de l’Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona, Santa Coloma de Gramenet, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Santa Coloma de Gramenet, SpainXarxa d’Innovació Alimentària, Barcelona, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona, Santa Coloma de Gramenet, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Santa Coloma de Gramenet, SpainXarxa d’Innovació Alimentària, Barcelona, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona, Santa Coloma de Gramenet, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Santa Coloma de Gramenet, SpainXarxa d’Innovació Alimentària, Barcelona, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona, Santa Coloma de Gramenet, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Santa Coloma de Gramenet, SpainXarxa d’Innovació Alimentària, Barcelona, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona, Santa Coloma de Gramenet, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Santa Coloma de Gramenet, SpainXarxa d’Innovació Alimentària, Barcelona, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona, Santa Coloma de Gramenet, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Santa Coloma de Gramenet, SpainXarxa d’Innovació Alimentària, Barcelona, SpainEfforts are currently being directed to identify a non-invasive marker that can serve as a solid and clinically irrefutable diagnostic criterion for histamine intolerance associated with diamine oxidase (DAO) deficiency. Accordingly, the identification of biomarkers of histamine (HA) metabolism in urine is proposed as a possible new diagnostic strategy. It is hypothesized that individuals with histamine intolerance could have a different urinary profile of HA and its metabolites in comparison with the healthy population. Thus, the aim of this study was to assess the urinary excretion of HA and 1-methylhistamine (MHA) in individuals diagnosed with histamine intolerance and in a control group. Levels of HA and MHA were compared between 24 h and first morning spot urine in a subgroup of 14 control individuals. Then, HA and MHA concentrations in spot urine of 32 histamine intolerant and 55 control individuals were determined by ultra-high performance liquid chromatography and fluorometric detection (UHPLC-FL) and normalized by creatinine. No differences were found between HA and MHA levels in 24 h and first morning samples. Overall, histamine intolerant patients presented a distinct urinary excretion profile compared to the control group due to lower levels of MHA. No differences in urinary MHA were observed related to serum DAO activity. Spot urine samples were thus validated as a reliable tool to determine the urinary excretion of HA and MHA. These results constitute a starting point for the study of HA metabolomics as a suitable and non-invasive approach to histamine intolerance diagnosis.https://www.frontiersin.org/articles/10.3389/fnut.2022.973682/fullhistamine1-methylhistaminehistamine intolerancediamine oxidase (DAO)DAO deficiencyfood intolerance |
| spellingShingle | Sònia Sánchez-Pérez Sònia Sánchez-Pérez Sònia Sánchez-Pérez Ricard Celorio-Sardà Ricard Celorio-Sardà Ricard Celorio-Sardà M. Teresa Veciana-Nogués M. Teresa Veciana-Nogués M. Teresa Veciana-Nogués M. Luz Latorre-Moratalla M. Luz Latorre-Moratalla M. Luz Latorre-Moratalla Oriol Comas-Basté Oriol Comas-Basté Oriol Comas-Basté M. Carmen Vidal-Carou M. Carmen Vidal-Carou M. Carmen Vidal-Carou 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study Frontiers in Nutrition histamine 1-methylhistamine histamine intolerance diamine oxidase (DAO) DAO deficiency food intolerance |
| title | 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study |
| title_full | 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study |
| title_fullStr | 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study |
| title_full_unstemmed | 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study |
| title_short | 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study |
| title_sort | 1 methylhistamine as a potential biomarker of food histamine intolerance a pilot study |
| topic | histamine 1-methylhistamine histamine intolerance diamine oxidase (DAO) DAO deficiency food intolerance |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.973682/full |
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