Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI
Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2023/5926340 |
| _version_ | 1797785538921496576 |
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| author | Patrick J. Beck John Benfield Joshua Morales |
| author_facet | Patrick J. Beck John Benfield Joshua Morales |
| author_sort | Patrick J. Beck |
| collection | DOAJ |
| description | Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting of acute coronary syndrome (ACS). Here, we present the case of a 52-year-old man presenting with chest pain and diagnosed with an NSTEMI but also found with a prolonged baseline aPTT ultimately secondary to FXII deficiency. Here, we discuss the diagnostic work-up of an isolated prolonged aPTT to identify possible etiologies, such as FXII deficiency, and ultimately inform ACS management. |
| first_indexed | 2024-03-13T00:56:25Z |
| format | Article |
| id | doaj.art-bf9c41a34c3d4c51bb779daac163a80b |
| institution | Directory Open Access Journal |
| issn | 2090-6579 |
| language | English |
| last_indexed | 2024-03-13T00:56:25Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj.art-bf9c41a34c3d4c51bb779daac163a80b2023-07-07T00:00:01ZengHindawi LimitedCase Reports in Hematology2090-65792023-01-01202310.1155/2023/5926340Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMIPatrick J. Beck0John Benfield1Joshua Morales2Virginia Tech Carilion School of MedicineVirginia Tech Carilion School of MedicineVirginia Tech Carilion School of MedicineFactor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting of acute coronary syndrome (ACS). Here, we present the case of a 52-year-old man presenting with chest pain and diagnosed with an NSTEMI but also found with a prolonged baseline aPTT ultimately secondary to FXII deficiency. Here, we discuss the diagnostic work-up of an isolated prolonged aPTT to identify possible etiologies, such as FXII deficiency, and ultimately inform ACS management.http://dx.doi.org/10.1155/2023/5926340 |
| spellingShingle | Patrick J. Beck John Benfield Joshua Morales Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI Case Reports in Hematology |
| title | Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI |
| title_full | Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI |
| title_fullStr | Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI |
| title_full_unstemmed | Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI |
| title_short | Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI |
| title_sort | friend or foe factor xii deficiency discovered incidentally during management of nstemi |
| url | http://dx.doi.org/10.1155/2023/5926340 |
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