Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19
Obesity prevails worldwide to an increasing effect. For example, up to 42% of American adults are considered obese. Obese individuals are prone to a variety of complications of metabolic disorders including diabetes mellitus, hypertension, cardiovascular disease, and chronic kidney disease. Recent m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.732913/full |
| _version_ | 1818727710325735424 |
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| author | Collins N. Khwatenge Marquette Pate Laura C. Miller Yongming Sang |
| author_facet | Collins N. Khwatenge Marquette Pate Laura C. Miller Yongming Sang |
| author_sort | Collins N. Khwatenge |
| collection | DOAJ |
| description | Obesity prevails worldwide to an increasing effect. For example, up to 42% of American adults are considered obese. Obese individuals are prone to a variety of complications of metabolic disorders including diabetes mellitus, hypertension, cardiovascular disease, and chronic kidney disease. Recent meta-analyses of clinical studies in patient cohorts in the ongoing coronavirus-disease 2019 (COVID-19) pandemic indicate that the presence of obesity and relevant disorders is linked to a more severe prognosis of COVID-19. Given the significance of obesity in COVID-19 progression, we provide a review of host metabolic and immune responses in the immunometabolic dysregulation exaggerated by obesity and the viral infection that develops into a severe course of COVID-19. Moreover, sequela studies of individuals 6 months after having COVID-19 show a higher risk of metabolic comorbidities including obesity, diabetes, and kidney disease. These collectively implicate an inter-systemic dimension to understanding the association between obesity and COVID-19 and suggest an interdisciplinary intervention for relief of obesity-COVID-19 complications beyond the phase of acute infection. |
| first_indexed | 2024-12-17T22:18:25Z |
| format | Article |
| id | doaj.art-bf9ce49b1c3f47e5af4995bc2d46021b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T22:18:25Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bf9ce49b1c3f47e5af4995bc2d46021b2022-12-21T21:30:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-10-011210.3389/fimmu.2021.732913732913Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19Collins N. Khwatenge0Marquette Pate1Laura C. Miller2Yongming Sang3Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, Nashville, TN, United StatesDepartment of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, Nashville, TN, United StatesVirus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA, United StatesDepartment of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, Nashville, TN, United StatesObesity prevails worldwide to an increasing effect. For example, up to 42% of American adults are considered obese. Obese individuals are prone to a variety of complications of metabolic disorders including diabetes mellitus, hypertension, cardiovascular disease, and chronic kidney disease. Recent meta-analyses of clinical studies in patient cohorts in the ongoing coronavirus-disease 2019 (COVID-19) pandemic indicate that the presence of obesity and relevant disorders is linked to a more severe prognosis of COVID-19. Given the significance of obesity in COVID-19 progression, we provide a review of host metabolic and immune responses in the immunometabolic dysregulation exaggerated by obesity and the viral infection that develops into a severe course of COVID-19. Moreover, sequela studies of individuals 6 months after having COVID-19 show a higher risk of metabolic comorbidities including obesity, diabetes, and kidney disease. These collectively implicate an inter-systemic dimension to understanding the association between obesity and COVID-19 and suggest an interdisciplinary intervention for relief of obesity-COVID-19 complications beyond the phase of acute infection.https://www.frontiersin.org/articles/10.3389/fimmu.2021.732913/fullobesitymetabolic disorderimmunometabolismCOVID-19immunopathy |
| spellingShingle | Collins N. Khwatenge Marquette Pate Laura C. Miller Yongming Sang Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19 Frontiers in Immunology obesity metabolic disorder immunometabolism COVID-19 immunopathy |
| title | Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19 |
| title_full | Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19 |
| title_fullStr | Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19 |
| title_full_unstemmed | Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19 |
| title_short | Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19 |
| title_sort | immunometabolic dysregulation at the intersection of obesity and covid 19 |
| topic | obesity metabolic disorder immunometabolism COVID-19 immunopathy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.732913/full |
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