Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect

Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect

Abstract Background Carvedilol, the anti-hypertensive drug, has poor bioavailability when administered orally. Ethosomes-mediated transdermal delivery is considered a potential route of administration to increase the bioavailability of carvedilol. The central composite design could be used as a tool...

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Bibliographic Details
Main Authors: Padmanabha Rao Amarachinta, Garima Sharma, Noufel Samed, Ananda Kumar Chettupalli, Madhusudhan Alle, Jin-Chul Kim
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Nanobiotechnology
Subjects:
Ethosomes
Carvedilol
Central composite design (CCD)
Ethosomal gel
Anti-hypertension
Online Access:https://doi.org/10.1186/s12951-021-00833-4

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