Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

Zebrafish Gdf3 (Dvr1) is a member of the TGFβ superfamily of cell signaling ligands that includes Xenopus Vg1 and mammalian Gdf1/3. Surprisingly, engineered homozygous mutants in zebrafish have no apparent phenotype. Elimination of Gdf3 in oocytes of maternal-zygotic mutants results in embryonic let...

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Bibliographic Details
Main Authors: Brent W Bisgrove, Yi-Chu Su, H Joseph Yost
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
Nodal
axis formation
patterning
Gdf3
Vg1
Online Access:https://elifesciences.org/articles/28534

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