Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of v...
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/3783 |
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| author | Laura Elena Pineda Lancheros Cristina Pérez Ramírez Almudena Sánchez Martín José María Gálvez Navas Fernando Martínez Martínez María del Carmen Ramírez Tortosa Alberto Jiménez Morales |
| author_facet | Laura Elena Pineda Lancheros Cristina Pérez Ramírez Almudena Sánchez Martín José María Gálvez Navas Fernando Martínez Martínez María del Carmen Ramírez Tortosa Alberto Jiménez Morales |
| author_sort | Laura Elena Pineda Lancheros |
| collection | DOAJ |
| description | Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study was designed as an observational cohort which included 194 Caucasians patients from southern Spain with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms: <i>CYP27B1</i> rs4646536, rs3782130, and rs10877012; <i>CYP24A1</i> rs6068816 and rs4809957; <i>GC</i> rs7041; <i>CYP2R1</i> rs10741657; <i>VDR</i> rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI), and rs731236 (TaqI). Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (<i>p</i> = 0.0233) and in the non-resected NSCLC subgroup (<i>p</i> = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (<i>p</i> = 0.0129) and rs7041 with PFS (<i>p</i> = 0.0447). In the non-resected NSCLC subgroup, rs6068816 was associated with PFS (<i>p</i> = 0.0048) and OS (<i>p</i> = 0.0089) and rs731236 and rs7975232 were associated with OS (<i>p</i> = 0.0005) and PFS (<i>p</i> = 0.0002), respectively. The other polymorphisms showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease. |
| first_indexed | 2024-03-10T05:12:11Z |
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| id | doaj.art-bf9fa9de08f24e2aa9dd67acdbddf3e6 |
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| language | English |
| last_indexed | 2024-03-10T05:12:11Z |
| publishDate | 2021-10-01 |
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| spelling | doaj.art-bf9fa9de08f24e2aa9dd67acdbddf3e62023-11-23T00:45:51ZengMDPI AGNutrients2072-66432021-10-011311378310.3390/nu13113783Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung CancerLaura Elena Pineda Lancheros0Cristina Pérez Ramírez1Almudena Sánchez Martín2José María Gálvez Navas3Fernando Martínez Martínez4María del Carmen Ramírez Tortosa5Alberto Jiménez Morales6Pharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, SpainPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, SpainPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, SpainPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, SpainDepartment of Pharmacy and Pharmaceutical Technology, Social and Legal Assistance Pharmacy Section, Faculty of Pharmacy, University of Granada, 18071 Granada, SpainCenter of Biomedical Research, Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, Avda. del Conocimiento s/n., 18016 Granada, SpainPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, SpainVitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study was designed as an observational cohort which included 194 Caucasians patients from southern Spain with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms: <i>CYP27B1</i> rs4646536, rs3782130, and rs10877012; <i>CYP24A1</i> rs6068816 and rs4809957; <i>GC</i> rs7041; <i>CYP2R1</i> rs10741657; <i>VDR</i> rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI), and rs731236 (TaqI). Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (<i>p</i> = 0.0233) and in the non-resected NSCLC subgroup (<i>p</i> = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (<i>p</i> = 0.0129) and rs7041 with PFS (<i>p</i> = 0.0447). In the non-resected NSCLC subgroup, rs6068816 was associated with PFS (<i>p</i> = 0.0048) and OS (<i>p</i> = 0.0089) and rs731236 and rs7975232 were associated with OS (<i>p</i> = 0.0005) and PFS (<i>p</i> = 0.0002), respectively. The other polymorphisms showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease.https://www.mdpi.com/2072-6643/13/11/3783vitamin D metabolismsurvivalnon-small-cell lung cancersingle nucleotide polymorphisms<i>CYP27B1</i><i>CYP24A1</i> |
| spellingShingle | Laura Elena Pineda Lancheros Cristina Pérez Ramírez Almudena Sánchez Martín José María Gálvez Navas Fernando Martínez Martínez María del Carmen Ramírez Tortosa Alberto Jiménez Morales Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer Nutrients vitamin D metabolism survival non-small-cell lung cancer single nucleotide polymorphisms <i>CYP27B1</i> <i>CYP24A1</i> |
| title | Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer |
| title_full | Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer |
| title_fullStr | Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer |
| title_full_unstemmed | Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer |
| title_short | Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer |
| title_sort | impact of genetic polymorphisms on the metabolic pathway of vitamin d and survival in non small cell lung cancer |
| topic | vitamin D metabolism survival non-small-cell lung cancer single nucleotide polymorphisms <i>CYP27B1</i> <i>CYP24A1</i> |
| url | https://www.mdpi.com/2072-6643/13/11/3783 |
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