cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach
Cancer is one of the most common causes of death globally. Despite extensive research and considerable advances in cancer therapy, the fundamentals of the disease remain unclear. Understanding the key signaling mechanisms that cause cancer cell malignancy may help to uncover new pharmaco-targets. Cy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/13/2020 |
| _version_ | 1827655162913619968 |
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| author | Muhammad Bilal Ahmed Abdullah A. A. Alghamdi Salman Ul Islam Joon-Seok Lee Young-Sup Lee |
| author_facet | Muhammad Bilal Ahmed Abdullah A. A. Alghamdi Salman Ul Islam Joon-Seok Lee Young-Sup Lee |
| author_sort | Muhammad Bilal Ahmed |
| collection | DOAJ |
| description | Cancer is one of the most common causes of death globally. Despite extensive research and considerable advances in cancer therapy, the fundamentals of the disease remain unclear. Understanding the key signaling mechanisms that cause cancer cell malignancy may help to uncover new pharmaco-targets. Cyclic adenosine monophosphate (cAMP) regulates various biological functions, including those in malignant cells. Understanding intracellular second messenger pathways is crucial for identifying downstream proteins involved in cancer growth and development. cAMP regulates cell signaling and a variety of physiological and pathological activities. There may be an impact on gene transcription from protein kinase A (PKA) as well as its downstream effectors, such as cAMP response element-binding protein (CREB). The position of CREB downstream of numerous growth signaling pathways implies its oncogenic potential in tumor cells. Tumor growth is associated with increased CREB expression and activation. PKA can be used as both an onco-drug target and a biomarker to find, identify, and stage tumors. Exploring cAMP effectors and their downstream pathways in cancer has become easier using exchange protein directly activated by cAMP (EPAC) modulators. This signaling system may inhibit or accelerate tumor growth depending on the tumor and its environment. As cAMP and its effectors are critical for cancer development, targeting them may be a useful cancer treatment strategy. Moreover, by reviewing the material from a distinct viewpoint, this review aims to give a knowledge of the impact of the cAMP signaling pathway and the related effectors on cancer incidence and development. These innovative insights seek to encourage the development of novel treatment techniques and new approaches. |
| first_indexed | 2024-03-09T22:01:53Z |
| format | Article |
| id | doaj.art-bfa1d21d5235488abce06f01d02df9dc |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:01:53Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bfa1d21d5235488abce06f01d02df9dc2023-11-23T19:48:11ZengMDPI AGCells2073-44092022-06-011113202010.3390/cells11132020cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric ApproachMuhammad Bilal Ahmed0Abdullah A. A. Alghamdi1Salman Ul Islam2Joon-Seok Lee3Young-Sup Lee4BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, KoreaDepartment of Biology, Faculty of Science, Albaha University, Albaha 65779, Saudi ArabiaDepartment of Pharmacy, Cecos University, Peshawar, Street 1, Sector F 5 Phase 6 Hayatabad, Peshawar 25000, PakistanBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, KoreaBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, KoreaCancer is one of the most common causes of death globally. Despite extensive research and considerable advances in cancer therapy, the fundamentals of the disease remain unclear. Understanding the key signaling mechanisms that cause cancer cell malignancy may help to uncover new pharmaco-targets. Cyclic adenosine monophosphate (cAMP) regulates various biological functions, including those in malignant cells. Understanding intracellular second messenger pathways is crucial for identifying downstream proteins involved in cancer growth and development. cAMP regulates cell signaling and a variety of physiological and pathological activities. There may be an impact on gene transcription from protein kinase A (PKA) as well as its downstream effectors, such as cAMP response element-binding protein (CREB). The position of CREB downstream of numerous growth signaling pathways implies its oncogenic potential in tumor cells. Tumor growth is associated with increased CREB expression and activation. PKA can be used as both an onco-drug target and a biomarker to find, identify, and stage tumors. Exploring cAMP effectors and their downstream pathways in cancer has become easier using exchange protein directly activated by cAMP (EPAC) modulators. This signaling system may inhibit or accelerate tumor growth depending on the tumor and its environment. As cAMP and its effectors are critical for cancer development, targeting them may be a useful cancer treatment strategy. Moreover, by reviewing the material from a distinct viewpoint, this review aims to give a knowledge of the impact of the cAMP signaling pathway and the related effectors on cancer incidence and development. These innovative insights seek to encourage the development of novel treatment techniques and new approaches.https://www.mdpi.com/2073-4409/11/13/2020cAMPPKACREBEPACtumor cell |
| spellingShingle | Muhammad Bilal Ahmed Abdullah A. A. Alghamdi Salman Ul Islam Joon-Seok Lee Young-Sup Lee cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach Cells cAMP PKA CREB EPAC tumor cell |
| title | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach |
| title_full | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach |
| title_fullStr | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach |
| title_full_unstemmed | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach |
| title_short | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach |
| title_sort | camp signaling in cancer a pka creb and epac centric approach |
| topic | cAMP PKA CREB EPAC tumor cell |
| url | https://www.mdpi.com/2073-4409/11/13/2020 |
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