Modeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies

Modeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies

Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. In this article, we describe a statistical mode...

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Bibliographic Details
Main Authors: Li eZhang, Ruitao eLiu, zhong ewang, Daniel eCulver, Rongling eWu
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Genetics
Subjects:
Linkage Disequilibrium
Epistasis
EM algorithm
haplotype
risk haplotype
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00002/full

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