New Insights on the Biomechanics of the Fetal Membrane
During pregnancy, the Fetal Membrane (FM) is subjected to mechanical stretching that may result in preterm labor. The structural integrity of the FM is maintained by its collagenous layer. Disconnection and reconnection of molecular bonds between collagen fibrils is the fundamental process that gove...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-06-01
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| Series: | Frontiers in Bioscience-Scholar |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBS/15/2/10.31083/j.fbs1502006 |
| _version_ | 1797789171292569600 |
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| author | Doron Shilo Eliezer Shalev |
| author_facet | Doron Shilo Eliezer Shalev |
| author_sort | Doron Shilo |
| collection | DOAJ |
| description | During pregnancy, the Fetal Membrane (FM) is subjected to mechanical stretching that may result in preterm labor. The structural integrity of the FM is maintained by its collagenous layer. Disconnection and reconnection of molecular bonds between collagen fibrils is the fundamental process that governs the irreversible mechanical and supramolecular changes in the FM. At a critical threshold strain, bundling and alignment of collagen fibrils alter the super-molecular structure of the collagenous layer. Recent studies indicate that these changes are associated with inflammation and/or expression of specific proteins that are known to be related to uterine contractions and labor. The potential healing of stretching-induced damages in the FM by mediators involved in mechano-transduction is discussed. |
| first_indexed | 2024-03-13T01:46:54Z |
| format | Article |
| id | doaj.art-bfa78fb053b242d09a910e1dd59f89ff |
| institution | Directory Open Access Journal |
| issn | 1945-0516 |
| language | English |
| last_indexed | 2024-03-13T01:46:54Z |
| publishDate | 2023-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Scholar |
| spelling | doaj.art-bfa78fb053b242d09a910e1dd59f89ff2023-07-03T07:41:46ZengIMR PressFrontiers in Bioscience-Scholar1945-05162023-06-01152610.31083/j.fbs1502006S1945-0516(23)00083-7New Insights on the Biomechanics of the Fetal MembraneDoron Shilo0Eliezer Shalev1Department of Mechanical Engineering, Technion, 3200003 Haifa, IsraelRappaport Faculty of Medicine, Technion, 3200003 Haifa, IsraelDuring pregnancy, the Fetal Membrane (FM) is subjected to mechanical stretching that may result in preterm labor. The structural integrity of the FM is maintained by its collagenous layer. Disconnection and reconnection of molecular bonds between collagen fibrils is the fundamental process that governs the irreversible mechanical and supramolecular changes in the FM. At a critical threshold strain, bundling and alignment of collagen fibrils alter the super-molecular structure of the collagenous layer. Recent studies indicate that these changes are associated with inflammation and/or expression of specific proteins that are known to be related to uterine contractions and labor. The potential healing of stretching-induced damages in the FM by mediators involved in mechano-transduction is discussed.https://www.imrpress.com/journal/FBS/15/2/10.31083/j.fbs1502006fetal membraneamnionchorionbiomechanicscollagen |
| spellingShingle | Doron Shilo Eliezer Shalev New Insights on the Biomechanics of the Fetal Membrane Frontiers in Bioscience-Scholar fetal membrane amnion chorion biomechanics collagen |
| title | New Insights on the Biomechanics of the Fetal Membrane |
| title_full | New Insights on the Biomechanics of the Fetal Membrane |
| title_fullStr | New Insights on the Biomechanics of the Fetal Membrane |
| title_full_unstemmed | New Insights on the Biomechanics of the Fetal Membrane |
| title_short | New Insights on the Biomechanics of the Fetal Membrane |
| title_sort | new insights on the biomechanics of the fetal membrane |
| topic | fetal membrane amnion chorion biomechanics collagen |
| url | https://www.imrpress.com/journal/FBS/15/2/10.31083/j.fbs1502006 |
| work_keys_str_mv | AT doronshilo newinsightsonthebiomechanicsofthefetalmembrane AT eliezershalev newinsightsonthebiomechanicsofthefetalmembrane |