Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia
Magnetic nanoparticle’s different applications in nanomedicine, due to their unique physical properties and biocompatibility, were intensively investigated. Recently, Fe₃O₄ nanoparticles, are confirmed to be the best sonosensitizers to enhance the performance of HIFU (high intensity focused ultrasou...
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| Format: | Article |
| Language: | English |
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Polish Academy of Sciences
2021-04-01
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| Series: | Bulletin of the Polish Academy of Sciences: Technical Sciences |
| Subjects: | |
| Online Access: | https://journals.pan.pl/Content/119619/PDF/31_01873_Bpast.No.69(3)_24.06.21_Druk.pdf |
| _version_ | 1811344024333713408 |
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| author | Barbara Gambin Eleonora Kruglenko |
| author_facet | Barbara Gambin Eleonora Kruglenko |
| author_sort | Barbara Gambin |
| collection | DOAJ |
| description | Magnetic nanoparticle’s different applications in nanomedicine, due to their unique physical properties and biocompatibility, were intensively investigated. Recently, Fe₃O₄ nanoparticles, are confirmed to be the best sonosensitizers to enhance the performance of HIFU (high intensity focused ultrasound). They are also used as thermo-sensitizers in magnetic hyperthermia. A new idea of dual, magneto-ultrasound, coupled hyperthermia allows the ultrasound intensity to be reduced from the high to a moderate level. Our goal is to evaluate the enhancement of thermal effects of focused ultrasound of moderate intensity due to the presence of nanoparticles. We combine experimental results with numerical analysis. Experiments are performed on tissue-mimicking materials made of the 5% agar gel and gel samples containing Fe₃O₄ nanoparticles with φ = 100 nm with two fractions of 0.76 and 1.53% w/w. Thermocouples registered curves of temperature rising during heating by focused ultrasound transducer with acoustic powers of the range from 1 to 4 W. The theoretical model of ultrasound-thermal coupling is solved in COMSOL Multiphysics. We compared the changes between the specific absorption rates (SAR) coefficients determined from the experimental and numerical temperature rise curves depending on the nanoparticle fractions and applied acoustic powers.We confirmed that the significant role of nanoparticles in enhancing the thermal effect is qualitatively similarly estimated, based on experimental and numerical results. So that we demonstrated the usefulness of the FEM linear acoustic model in the planning of efficiency of nanoparticle-mediated moderate hyperthermia. |
| first_indexed | 2024-04-13T19:40:22Z |
| format | Article |
| id | doaj.art-bfa8c6f40df94e8495cf41e921fb8396 |
| institution | Directory Open Access Journal |
| issn | 2300-1917 |
| language | English |
| last_indexed | 2024-04-13T19:40:22Z |
| publishDate | 2021-04-01 |
| publisher | Polish Academy of Sciences |
| record_format | Article |
| series | Bulletin of the Polish Academy of Sciences: Technical Sciences |
| spelling | doaj.art-bfa8c6f40df94e8495cf41e921fb83962022-12-22T02:32:55ZengPolish Academy of SciencesBulletin of the Polish Academy of Sciences: Technical Sciences2300-19172021-04-01693https://doi.org/10.24425/bpasts.2021.137053Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermiaBarbara Gambin0https://orcid.org/0000-0001-7212-0157Eleonora Kruglenko1Institute of Fundamental Technological Research, Polish Academy of Sciences, ul. Pawińskiego 5B, 02-106 Warsaw, PolandInstitute of Fundamental Technological Research, Polish Academy of Sciences, ul. Pawińskiego 5B, 02-106 Warsaw, PolandMagnetic nanoparticle’s different applications in nanomedicine, due to their unique physical properties and biocompatibility, were intensively investigated. Recently, Fe₃O₄ nanoparticles, are confirmed to be the best sonosensitizers to enhance the performance of HIFU (high intensity focused ultrasound). They are also used as thermo-sensitizers in magnetic hyperthermia. A new idea of dual, magneto-ultrasound, coupled hyperthermia allows the ultrasound intensity to be reduced from the high to a moderate level. Our goal is to evaluate the enhancement of thermal effects of focused ultrasound of moderate intensity due to the presence of nanoparticles. We combine experimental results with numerical analysis. Experiments are performed on tissue-mimicking materials made of the 5% agar gel and gel samples containing Fe₃O₄ nanoparticles with φ = 100 nm with two fractions of 0.76 and 1.53% w/w. Thermocouples registered curves of temperature rising during heating by focused ultrasound transducer with acoustic powers of the range from 1 to 4 W. The theoretical model of ultrasound-thermal coupling is solved in COMSOL Multiphysics. We compared the changes between the specific absorption rates (SAR) coefficients determined from the experimental and numerical temperature rise curves depending on the nanoparticle fractions and applied acoustic powers.We confirmed that the significant role of nanoparticles in enhancing the thermal effect is qualitatively similarly estimated, based on experimental and numerical results. So that we demonstrated the usefulness of the FEM linear acoustic model in the planning of efficiency of nanoparticle-mediated moderate hyperthermia.https://journals.pan.pl/Content/119619/PDF/31_01873_Bpast.No.69(3)_24.06.21_Druk.pdfultrasonic hyperthermiaagar-based tissue mimicking phantommagnetic nanoparticlestemperaturespecific absorption rate (sar) |
| spellingShingle | Barbara Gambin Eleonora Kruglenko Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia Bulletin of the Polish Academy of Sciences: Technical Sciences ultrasonic hyperthermia agar-based tissue mimicking phantom magnetic nanoparticles temperature specific absorption rate (sar) |
| title | Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia |
| title_full | Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia |
| title_fullStr | Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia |
| title_full_unstemmed | Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia |
| title_short | Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia |
| title_sort | ultrasonic specific absorption rate in nanoparticle mediated moderate hyperthermia |
| topic | ultrasonic hyperthermia agar-based tissue mimicking phantom magnetic nanoparticles temperature specific absorption rate (sar) |
| url | https://journals.pan.pl/Content/119619/PDF/31_01873_Bpast.No.69(3)_24.06.21_Druk.pdf |
| work_keys_str_mv | AT barbaragambin ultrasonicspecificabsorptionrateinnanoparticlemediatedmoderatehyperthermia AT eleonorakruglenko ultrasonicspecificabsorptionrateinnanoparticlemediatedmoderatehyperthermia |