Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes
Green biosynthesis, one of the most dependable and cost-effective methods for producing carbon nanotubes, was used to synthesize nonhazardous silver-functionalized multi-walled carbon nanotubes (SFMWCNTs) successfully. It has been shown that the water-soluble organic materials present in the olive o...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/224 |
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| author | Hassna Mohammed Alhajri Sadeem Salih Aloqaili Seham S. Alterary Aljawharah Alqathama Ashraf N. Abdalla Rami M. Alzhrani Bander S. Alotaibi Hashem O. Alsaab |
| author_facet | Hassna Mohammed Alhajri Sadeem Salih Aloqaili Seham S. Alterary Aljawharah Alqathama Ashraf N. Abdalla Rami M. Alzhrani Bander S. Alotaibi Hashem O. Alsaab |
| author_sort | Hassna Mohammed Alhajri |
| collection | DOAJ |
| description | Green biosynthesis, one of the most dependable and cost-effective methods for producing carbon nanotubes, was used to synthesize nonhazardous silver-functionalized multi-walled carbon nanotubes (SFMWCNTs) successfully. It has been shown that the water-soluble organic materials present in the olive oil plant play a vital role in converting silver ions into silver nanoparticles (Ag-NPs). Olive-leaf extracts contain medicinal properties and combining these extracts with Ag-NPs is often a viable option for enhancing drug delivery; thus, this possibility was employed for in vitro treating cancer cells as a proof of concept. In this study, the green technique for preparing SFMWCNTs composites using plant extracts was followed. This process yielded various compounds, the most important of which were Hydroxytyrosol, Tyrosol, and Oleuropein. Subsequently, a thin film was fabricated from the extract, resulting in a natural polymer. The obtained nanomaterials have an absorption peak of 419 nm in their UV–Vis. spectra. SEM and EDS were also used to investigate the SFMWCNT nanocomposites’ morphology simultaneously. Moreover, the MTT assay was used to evaluate the ability of SFMWCNTs to suppress cancer cell viability on different cancer cell lines, MCF7 (human breast adenocarcinoma), HepG2 (human hepatocellular carcinoma), and SW620 (human colorectal cancer). Using varying doses of SFMWCNT resulted in the most significant cell viability inhibition, indicating the good sensitivity of SFMWCNTs for treating cancer cells. It was found that performing olive-leaf extraction at a low temperature in an ice bath leads to superior results, and the developed SFMWCNT nanocomposites could be potential treatment options for in vitro cancer cells. |
| first_indexed | 2024-03-09T16:16:08Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:16:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-bfa8d5365fb64829ae607f0ecbc426592023-11-24T15:49:46ZengMDPI AGJournal of Functional Biomaterials2079-49832022-11-0113422410.3390/jfb13040224Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon NanotubesHassna Mohammed Alhajri0Sadeem Salih Aloqaili1Seham S. Alterary2Aljawharah Alqathama3Ashraf N. Abdalla4Rami M. Alzhrani5Bander S. Alotaibi6Hashem O. Alsaab7King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi ArabiaKACST-Oxford Petrochemical Research Center (KOPRC), King Abdulaziz City for Science and Technology, Riyadh 11542, Saudi ArabiaChemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif 21944, Saudi ArabiaChemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif 21944, Saudi ArabiaGreen biosynthesis, one of the most dependable and cost-effective methods for producing carbon nanotubes, was used to synthesize nonhazardous silver-functionalized multi-walled carbon nanotubes (SFMWCNTs) successfully. It has been shown that the water-soluble organic materials present in the olive oil plant play a vital role in converting silver ions into silver nanoparticles (Ag-NPs). Olive-leaf extracts contain medicinal properties and combining these extracts with Ag-NPs is often a viable option for enhancing drug delivery; thus, this possibility was employed for in vitro treating cancer cells as a proof of concept. In this study, the green technique for preparing SFMWCNTs composites using plant extracts was followed. This process yielded various compounds, the most important of which were Hydroxytyrosol, Tyrosol, and Oleuropein. Subsequently, a thin film was fabricated from the extract, resulting in a natural polymer. The obtained nanomaterials have an absorption peak of 419 nm in their UV–Vis. spectra. SEM and EDS were also used to investigate the SFMWCNT nanocomposites’ morphology simultaneously. Moreover, the MTT assay was used to evaluate the ability of SFMWCNTs to suppress cancer cell viability on different cancer cell lines, MCF7 (human breast adenocarcinoma), HepG2 (human hepatocellular carcinoma), and SW620 (human colorectal cancer). Using varying doses of SFMWCNT resulted in the most significant cell viability inhibition, indicating the good sensitivity of SFMWCNTs for treating cancer cells. It was found that performing olive-leaf extraction at a low temperature in an ice bath leads to superior results, and the developed SFMWCNT nanocomposites could be potential treatment options for in vitro cancer cells.https://www.mdpi.com/2079-4983/13/4/224green biosynthesisnanotechnologysilver nanoparticlescarbon nanotubes<i>Olea europaea</i>olive extracts |
| spellingShingle | Hassna Mohammed Alhajri Sadeem Salih Aloqaili Seham S. Alterary Aljawharah Alqathama Ashraf N. Abdalla Rami M. Alzhrani Bander S. Alotaibi Hashem O. Alsaab Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes Journal of Functional Biomaterials green biosynthesis nanotechnology silver nanoparticles carbon nanotubes <i>Olea europaea</i> olive extracts |
| title | Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes |
| title_full | Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes |
| title_fullStr | Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes |
| title_full_unstemmed | Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes |
| title_short | Olive Leaf Extracts for a Green Synthesis of Silver-Functionalized Multi-Walled Carbon Nanotubes |
| title_sort | olive leaf extracts for a green synthesis of silver functionalized multi walled carbon nanotubes |
| topic | green biosynthesis nanotechnology silver nanoparticles carbon nanotubes <i>Olea europaea</i> olive extracts |
| url | https://www.mdpi.com/2079-4983/13/4/224 |
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