Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer
Metabolic reprogramming is a well described hallmark of cancer. Oncogenic stimuli and the microenvironment shape the metabolic phenotype of cancer cells, causing pathological modifications of carbohydrate, amino acid and lipid metabolism that support the uncontrolled growth and proliferation of canc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/14/3485 |
| _version_ | 1797527483490238464 |
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| author | Assunta Sellitto Giovanni Pecoraro Giorgio Giurato Giovanni Nassa Francesca Rizzo Pasquale Saggese Cesar A. Martinez Claudio Scafoglio Roberta Tarallo |
| author_facet | Assunta Sellitto Giovanni Pecoraro Giorgio Giurato Giovanni Nassa Francesca Rizzo Pasquale Saggese Cesar A. Martinez Claudio Scafoglio Roberta Tarallo |
| author_sort | Assunta Sellitto |
| collection | DOAJ |
| description | Metabolic reprogramming is a well described hallmark of cancer. Oncogenic stimuli and the microenvironment shape the metabolic phenotype of cancer cells, causing pathological modifications of carbohydrate, amino acid and lipid metabolism that support the uncontrolled growth and proliferation of cancer cells. Conversely, metabolic alterations in cancer can drive changes in genetic programs affecting cell proliferation and differentiation. In recent years, the role of non-coding RNAs in metabolic reprogramming in cancer has been extensively studied. Here, we review this topic, with a focus on glucose, glutamine, and lipid metabolism and point to some evidence that metabolic alterations occurring in cancer can drive changes in non-coding RNA expression, thus adding an additional level of complexity in the relationship between metabolism and genetic programs in cancer cells. |
| first_indexed | 2024-03-10T09:44:21Z |
| format | Article |
| id | doaj.art-bfa8f08bc88c4a83ab7a5bf33ebb8cb9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:44:21Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bfa8f08bc88c4a83ab7a5bf33ebb8cb92023-11-22T03:24:01ZengMDPI AGCancers2072-66942021-07-011314348510.3390/cancers13143485Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in CancerAssunta Sellitto0Giovanni Pecoraro1Giorgio Giurato2Giovanni Nassa3Francesca Rizzo4Pasquale Saggese5Cesar A. Martinez6Claudio Scafoglio7Roberta Tarallo8Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, ItalyLaboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, ItalyLaboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, ItalyLaboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, ItalyLaboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, ItalyDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USALaboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, ItalyMetabolic reprogramming is a well described hallmark of cancer. Oncogenic stimuli and the microenvironment shape the metabolic phenotype of cancer cells, causing pathological modifications of carbohydrate, amino acid and lipid metabolism that support the uncontrolled growth and proliferation of cancer cells. Conversely, metabolic alterations in cancer can drive changes in genetic programs affecting cell proliferation and differentiation. In recent years, the role of non-coding RNAs in metabolic reprogramming in cancer has been extensively studied. Here, we review this topic, with a focus on glucose, glutamine, and lipid metabolism and point to some evidence that metabolic alterations occurring in cancer can drive changes in non-coding RNA expression, thus adding an additional level of complexity in the relationship between metabolism and genetic programs in cancer cells.https://www.mdpi.com/2072-6694/13/14/3485cancer metabolismlong non-coding RNAsmetabolic reprogrammingglycolysisWarburg effectglutaminolysis |
| spellingShingle | Assunta Sellitto Giovanni Pecoraro Giorgio Giurato Giovanni Nassa Francesca Rizzo Pasquale Saggese Cesar A. Martinez Claudio Scafoglio Roberta Tarallo Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer Cancers cancer metabolism long non-coding RNAs metabolic reprogramming glycolysis Warburg effect glutaminolysis |
| title | Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer |
| title_full | Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer |
| title_fullStr | Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer |
| title_full_unstemmed | Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer |
| title_short | Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer |
| title_sort | regulation of metabolic reprogramming by long non coding rnas in cancer |
| topic | cancer metabolism long non-coding RNAs metabolic reprogramming glycolysis Warburg effect glutaminolysis |
| url | https://www.mdpi.com/2072-6694/13/14/3485 |
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