Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis
Antioxidant intake has been suggested to be associated with the prognosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether dietary total antioxidant capacity (DTAC) and that of major food groups are related to disease progression rate (ΔFS) and survival time in ALS pat...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/16/3264 |
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| author | Jihyun Eom Bugyeong Son Seung Hyun Kim Yongsoon Park |
| author_facet | Jihyun Eom Bugyeong Son Seung Hyun Kim Yongsoon Park |
| author_sort | Jihyun Eom |
| collection | DOAJ |
| description | Antioxidant intake has been suggested to be associated with the prognosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether dietary total antioxidant capacity (DTAC) and that of major food groups are related to disease progression rate (ΔFS) and survival time in ALS patients. A total of 301 participants diagnosed with sporadic ALS according to the revised El Escorial criteria were recruited from March 2011 and followed up to the event occurrence, or the end of October 2021. Events included percutaneous endoscopic gastrostomy, tracheostomy, and death. DTAC was estimated using task automation and an algorithm based on 24 h dietary recall. ΔFS was negatively correlated with the vegetable and legume DTAC, and event-free survival was different among the tertiles of vegetables and legumes DTAC. Consistently, the risk of events was negatively associated with DTAC from vegetables and legumes. These results suggest that the intake of antioxidants, especially those derived from vegetables and legumes, has a beneficial effect on delaying disease progression and prolonging survival in patients with ALS. Further studies with large prospective cohorts and clinical trials are needed to determine whether the consumption of foods with high DTAC improves the prognosis of ALS. |
| first_indexed | 2024-03-09T04:00:46Z |
| format | Article |
| id | doaj.art-bfaa8aa38e29482ea29f1b9de3eeb001 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T04:00:46Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-bfaa8aa38e29482ea29f1b9de3eeb0012023-12-03T14:13:49ZengMDPI AGNutrients2072-66432022-08-011416326410.3390/nu14163264Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral SclerosisJihyun Eom0Bugyeong Son1Seung Hyun Kim2Yongsoon Park3Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaCell Therapy Center, Hanyang University Hospital, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaCell Therapy Center, Hanyang University Hospital, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaDepartment of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaAntioxidant intake has been suggested to be associated with the prognosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether dietary total antioxidant capacity (DTAC) and that of major food groups are related to disease progression rate (ΔFS) and survival time in ALS patients. A total of 301 participants diagnosed with sporadic ALS according to the revised El Escorial criteria were recruited from March 2011 and followed up to the event occurrence, or the end of October 2021. Events included percutaneous endoscopic gastrostomy, tracheostomy, and death. DTAC was estimated using task automation and an algorithm based on 24 h dietary recall. ΔFS was negatively correlated with the vegetable and legume DTAC, and event-free survival was different among the tertiles of vegetables and legumes DTAC. Consistently, the risk of events was negatively associated with DTAC from vegetables and legumes. These results suggest that the intake of antioxidants, especially those derived from vegetables and legumes, has a beneficial effect on delaying disease progression and prolonging survival in patients with ALS. Further studies with large prospective cohorts and clinical trials are needed to determine whether the consumption of foods with high DTAC improves the prognosis of ALS.https://www.mdpi.com/2072-6643/14/16/3264amyotrophic lateral sclerosisdietary total antioxidant capacitydisease progression rateevent-free survival |
| spellingShingle | Jihyun Eom Bugyeong Son Seung Hyun Kim Yongsoon Park Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis Nutrients amyotrophic lateral sclerosis dietary total antioxidant capacity disease progression rate event-free survival |
| title | Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis |
| title_full | Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis |
| title_fullStr | Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis |
| title_short | Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis |
| title_sort | relationship between dietary total antioxidant capacity and the prognosis of amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis dietary total antioxidant capacity disease progression rate event-free survival |
| url | https://www.mdpi.com/2072-6643/14/16/3264 |
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