Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study
Xiawan Yang, 1,* Yanliang Bai, 1,* Mingyue Shi, 1 Wanjun Zhang, 1 Junwei Niu, 1 Chengye Wu, 2 Lei Zhang, 2 Zhiwei Xu, 3 Xiang Liu, 4 Yuqing Chen, 1 Kai Sun 1 1Department of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People&a...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-02-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/validation-of-the-eutos-long-term-survival-score-in-chinese-chronic-my-peer-reviewed-article-CMAR |
| _version_ | 1818143676045459456 |
|---|---|
| author | Yang X Bai Y Shi M Zhang W Niu J Wu C Zhang L Xu Z Liu X Chen Y Sun K |
| author_facet | Yang X Bai Y Shi M Zhang W Niu J Wu C Zhang L Xu Z Liu X Chen Y Sun K |
| author_sort | Yang X |
| collection | DOAJ |
| description | Xiawan Yang, 1,* Yanliang Bai, 1,* Mingyue Shi, 1 Wanjun Zhang, 1 Junwei Niu, 1 Chengye Wu, 2 Lei Zhang, 2 Zhiwei Xu, 3 Xiang Liu, 4 Yuqing Chen, 1 Kai Sun 1 1Department of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China; 2Institute of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China; 3Department of Clinical Research Service Center, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China; 4Department of Geriatric Medicine, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Sun; Yuqing ChenDepartment of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jinshui District Zhengzhou, Henan 450003, People’s Republic of ChinaTel +86-18237110038; +86-18697321863Email sunkai@cellscience.org; henanblood@sina.comPurpose: To validate the clinical efficacy of the recently developed EUTOS long-term survival (ELTS) score in a real-world setting.Patients and Methods: A total of 479 chronic myeloid leukemia (CML) patients treated with frontline imatinib between January 2010 and December 2017 were enrolled in this retrospective study. The ELTS score was evaluated on the end-points including complete cytogenetic response (CCyR), progression-free survival (PFS), overall survival (OS) and CML-related death, and the efficiency of the ELTS score was further compared with the historical Sokal, Hasford, EUTOS scores.Results: With a median follow-up of 69 months (range, 9– 112 months), 462 evaluable patients were stratified into the ELTS low-risk (n = 230), ELTS intermediate-risk (n = 168) and ELTS high-risk (n = 64) groups. For the regular assessment indicators like CCyR, PFS and OS, the ELTS scoring system could effectively identify the corresponding risk groups, similarly with the results provided by previous scoring systems. With respect to the CML-related death, the ELTS score could accurately identify a high-risk group with a significantly higher risk of dying of CML, and the 5-year cumulative incidence occurred in the ELTS high-, intermediate-, and low-risk groups was 11% (95% CI: 3– 19%), 5% (95% CI: 1– 9%) and 2% (95% CI: 0– 4%), respectively. Most notably, the ELTS score outperformed the Sokal, Hasford and EUTOS scores without statistical difference among different risk groups.Conclusion: The ELTS score could effectively predict the prognosis of imatinib-treated CML patients in real-life settings.Keywords: chronic myeloid leukemia, tyrosine kinase inhibitors, Sokal, Hasford, EUTOS, EUTOS long-term survival score |
| first_indexed | 2024-12-11T11:35:27Z |
| format | Article |
| id | doaj.art-bfae70fafeed464890165d6bd9374f89 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-11T11:35:27Z |
| publishDate | 2020-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-bfae70fafeed464890165d6bd9374f892022-12-22T01:08:46ZengDove Medical PressCancer Management and Research1179-13222020-02-01Volume 121293130151983Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World StudyYang XBai YShi MZhang WNiu JWu CZhang LXu ZLiu XChen YSun KXiawan Yang, 1,* Yanliang Bai, 1,* Mingyue Shi, 1 Wanjun Zhang, 1 Junwei Niu, 1 Chengye Wu, 2 Lei Zhang, 2 Zhiwei Xu, 3 Xiang Liu, 4 Yuqing Chen, 1 Kai Sun 1 1Department of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China; 2Institute of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China; 3Department of Clinical Research Service Center, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China; 4Department of Geriatric Medicine, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Sun; Yuqing ChenDepartment of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jinshui District Zhengzhou, Henan 450003, People’s Republic of ChinaTel +86-18237110038; +86-18697321863Email sunkai@cellscience.org; henanblood@sina.comPurpose: To validate the clinical efficacy of the recently developed EUTOS long-term survival (ELTS) score in a real-world setting.Patients and Methods: A total of 479 chronic myeloid leukemia (CML) patients treated with frontline imatinib between January 2010 and December 2017 were enrolled in this retrospective study. The ELTS score was evaluated on the end-points including complete cytogenetic response (CCyR), progression-free survival (PFS), overall survival (OS) and CML-related death, and the efficiency of the ELTS score was further compared with the historical Sokal, Hasford, EUTOS scores.Results: With a median follow-up of 69 months (range, 9– 112 months), 462 evaluable patients were stratified into the ELTS low-risk (n = 230), ELTS intermediate-risk (n = 168) and ELTS high-risk (n = 64) groups. For the regular assessment indicators like CCyR, PFS and OS, the ELTS scoring system could effectively identify the corresponding risk groups, similarly with the results provided by previous scoring systems. With respect to the CML-related death, the ELTS score could accurately identify a high-risk group with a significantly higher risk of dying of CML, and the 5-year cumulative incidence occurred in the ELTS high-, intermediate-, and low-risk groups was 11% (95% CI: 3– 19%), 5% (95% CI: 1– 9%) and 2% (95% CI: 0– 4%), respectively. Most notably, the ELTS score outperformed the Sokal, Hasford and EUTOS scores without statistical difference among different risk groups.Conclusion: The ELTS score could effectively predict the prognosis of imatinib-treated CML patients in real-life settings.Keywords: chronic myeloid leukemia, tyrosine kinase inhibitors, Sokal, Hasford, EUTOS, EUTOS long-term survival scorehttps://www.dovepress.com/validation-of-the-eutos-long-term-survival-score-in-chinese-chronic-my-peer-reviewed-article-CMARchronic myeloid leukemiatyrosine kinase inhibitorssokalhasfordeutoseutos long-term survival score |
| spellingShingle | Yang X Bai Y Shi M Zhang W Niu J Wu C Zhang L Xu Z Liu X Chen Y Sun K Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study Cancer Management and Research chronic myeloid leukemia tyrosine kinase inhibitors sokal hasford eutos eutos long-term survival score |
| title | Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study |
| title_full | Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study |
| title_fullStr | Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study |
| title_full_unstemmed | Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study |
| title_short | Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study |
| title_sort | validation of the eutos long term survival score in chinese chronic myeloid leukemia patients treated with imatinib a multicenter real world study |
| topic | chronic myeloid leukemia tyrosine kinase inhibitors sokal hasford eutos eutos long-term survival score |
| url | https://www.dovepress.com/validation-of-the-eutos-long-term-survival-score-in-chinese-chronic-my-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT yangx validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT baiy validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT shim validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT zhangw validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT niuj validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT wuc validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT zhangl validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT xuz validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT liux validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT cheny validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy AT sunk validationoftheeutoslongtermsurvivalscoreinchinesechronicmyeloidleukemiapatientstreatedwithimatinibamulticenterrealworldstudy |