Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

Increasing evidence highlights the important roles of microRNAs in mediating p53’s tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an...

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Bibliographic Details
Main Authors: Bo Cao, Kebing Wang, Jun-Ming Liao, Xiang Zhou, Peng Liao, Shelya X Zeng, Meifang He, Lianzhou Chen, Yulong He, Wen Li, Hua Lu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
p53
miR-139-5p
PDE4D
BIM
apoptosis
tumor suppression
Online Access:https://elifesciences.org/articles/15978

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