A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
Xue Yang,1 Weigang Wu,2 Yongjie Wang,1 Wen Wu,1 Xia Huang,1 Li Xu3 1Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, Peopl...
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Dove Medical Press
2022-09-01
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author | Yang X Wu W Wang Y Wu W Huang X Xu L |
author_facet | Yang X Wu W Wang Y Wu W Huang X Xu L |
author_sort | Yang X |
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description | Xue Yang,1 Weigang Wu,2 Yongjie Wang,1 Wen Wu,1 Xia Huang,1 Li Xu3 1Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 2Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, People’s Republic of ChinaCorrespondence: Li Xu, Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, People’s Republic of China, Email 419176498@qq.comAbstract: Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum was suggested by a positive mNGS result in BALF. One month after treatment with benzathine penicillin G (2.4 million units, three doses), a repeated CT scan showed the radiological resolution. To our knowledge, this is the first reported case of secondary pulmonary syphilis diagnosed by mNGS in BALF.Keywords: pulmonary, secondary syphilis, Treponema pallidum, mNGS |
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format | Article |
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issn | 1178-6973 |
language | English |
last_indexed | 2024-04-12T23:45:13Z |
publishDate | 2022-09-01 |
publisher | Dove Medical Press |
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series | Infection and Drug Resistance |
spelling | doaj.art-bfb365b30d69453aa860c49e218222c72022-12-22T03:11:53ZengDove Medical PressInfection and Drug Resistance1178-69732022-09-01Volume 155215521977945A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case ReportYang XWu WWang YWu WHuang XXu LXue Yang,1 Weigang Wu,2 Yongjie Wang,1 Wen Wu,1 Xia Huang,1 Li Xu3 1Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 2Department of Infectious Disease, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, People’s Republic of ChinaCorrespondence: Li Xu, Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, People’s Republic of China, Email 419176498@qq.comAbstract: Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum was suggested by a positive mNGS result in BALF. One month after treatment with benzathine penicillin G (2.4 million units, three doses), a repeated CT scan showed the radiological resolution. To our knowledge, this is the first reported case of secondary pulmonary syphilis diagnosed by mNGS in BALF.Keywords: pulmonary, secondary syphilis, Treponema pallidum, mNGShttps://www.dovepress.com/a-case-of-secondary-pulmonary-syphilis--the-utility-of-mngs-in-broncho-peer-reviewed-fulltext-article-IDRpulmonarysecondary syphilistreponema pallidummngs |
spellingShingle | Yang X Wu W Wang Y Wu W Huang X Xu L A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report Infection and Drug Resistance pulmonary secondary syphilis treponema pallidum mngs |
title | A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report |
title_full | A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report |
title_fullStr | A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report |
title_full_unstemmed | A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report |
title_short | A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report |
title_sort | case of secondary pulmonary syphilis ndash the utility of mngs in bronchoalveolar lavage fluid a case report |
topic | pulmonary secondary syphilis treponema pallidum mngs |
url | https://www.dovepress.com/a-case-of-secondary-pulmonary-syphilis--the-utility-of-mngs-in-broncho-peer-reviewed-fulltext-article-IDR |
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