Role of lncRNA BANCR in Human Cancers: An Updated Review
Being located in a gene desert region on 9q21.11-q21.12, BRAF-activated non-protein coding RNA (BANCR) is an lncRNA with 693 bp length. It has been discovered in 2012 in a research aimed at assessment of gene expression in the melanocytes in association with BRAF mutation. Increasing numbers of stud...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.689992/full |
| _version_ | 1818348313149177856 |
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| author | Bashdar Mahmud Hussen Tahereh Azimi Atefe Abak Hazha Jamal Hidayat Mohammad Taheri Soudeh Ghafouri-Fard |
| author_facet | Bashdar Mahmud Hussen Tahereh Azimi Atefe Abak Hazha Jamal Hidayat Mohammad Taheri Soudeh Ghafouri-Fard |
| author_sort | Bashdar Mahmud Hussen |
| collection | DOAJ |
| description | Being located in a gene desert region on 9q21.11-q21.12, BRAF-activated non-protein coding RNA (BANCR) is an lncRNA with 693 bp length. It has been discovered in 2012 in a research aimed at assessment of gene expression in the melanocytes in association with BRAF mutation. Increasing numbers of studies have determined its importance in the tumorigenesis through affecting cell proliferation, migration, invasion, apoptosis, and epithelial to mesenchymal transition. BANCR exerts its effects via modulating some tumor-related signaling pathways particularly MAPK and other regulatory mechanisms such as sponging miRNAs. BANCR has been up-regulated in endometrial, gastric, breast, melanoma, and retinoblastoma. Conversely, it has been down-regulated in some other cancers such as those originated from lung, bladder, and renal tissues. In some cancer types such as colorectal cancer, hepatocellular carcinoma and papillary thyroid carcinoma, there is no agreement about BANCR expression, necessitating the importance of additional functional studies in these tissues. In the present manuscript, we review the investigations related to BANCR expression changes in cancerous cell lines, clinical samples, and animal models of cancer. We also discuss the outcome of its deregulation in cancer progression, prognosis, and the underlying mechanisms of these observations. |
| first_indexed | 2024-12-13T17:48:04Z |
| format | Article |
| id | doaj.art-bfb410e7f4f648e8826557933585f011 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T17:48:04Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-bfb410e7f4f648e8826557933585f0112022-12-21T23:36:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.689992689992Role of lncRNA BANCR in Human Cancers: An Updated ReviewBashdar Mahmud Hussen0Tahereh Azimi1Atefe Abak2Hazha Jamal Hidayat3Mohammad Taheri4Soudeh Ghafouri-Fard5Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Biology, College of Education, Salahadddin University-Erbil, Erbil, IraqSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IranBeing located in a gene desert region on 9q21.11-q21.12, BRAF-activated non-protein coding RNA (BANCR) is an lncRNA with 693 bp length. It has been discovered in 2012 in a research aimed at assessment of gene expression in the melanocytes in association with BRAF mutation. Increasing numbers of studies have determined its importance in the tumorigenesis through affecting cell proliferation, migration, invasion, apoptosis, and epithelial to mesenchymal transition. BANCR exerts its effects via modulating some tumor-related signaling pathways particularly MAPK and other regulatory mechanisms such as sponging miRNAs. BANCR has been up-regulated in endometrial, gastric, breast, melanoma, and retinoblastoma. Conversely, it has been down-regulated in some other cancers such as those originated from lung, bladder, and renal tissues. In some cancer types such as colorectal cancer, hepatocellular carcinoma and papillary thyroid carcinoma, there is no agreement about BANCR expression, necessitating the importance of additional functional studies in these tissues. In the present manuscript, we review the investigations related to BANCR expression changes in cancerous cell lines, clinical samples, and animal models of cancer. We also discuss the outcome of its deregulation in cancer progression, prognosis, and the underlying mechanisms of these observations.https://www.frontiersin.org/articles/10.3389/fcell.2021.689992/fullBANCRlncRNAbiomarkercancerexpression |
| spellingShingle | Bashdar Mahmud Hussen Tahereh Azimi Atefe Abak Hazha Jamal Hidayat Mohammad Taheri Soudeh Ghafouri-Fard Role of lncRNA BANCR in Human Cancers: An Updated Review Frontiers in Cell and Developmental Biology BANCR lncRNA biomarker cancer expression |
| title | Role of lncRNA BANCR in Human Cancers: An Updated Review |
| title_full | Role of lncRNA BANCR in Human Cancers: An Updated Review |
| title_fullStr | Role of lncRNA BANCR in Human Cancers: An Updated Review |
| title_full_unstemmed | Role of lncRNA BANCR in Human Cancers: An Updated Review |
| title_short | Role of lncRNA BANCR in Human Cancers: An Updated Review |
| title_sort | role of lncrna bancr in human cancers an updated review |
| topic | BANCR lncRNA biomarker cancer expression |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.689992/full |
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