Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer
Background: Circadian rhythm is an internal timing system generated by circadian-related genes (CRGs). Disruption in this rhythm has been associated with a heightened risk of breast cancer (BC) and regulation of the immune microenvironment of tumors. This study aimed to investigate the clinical sign...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024033875 |
| _version_ | 1827294055872069632 |
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| author | Chunjie Sun Hanyun Zhang Ye Li Yang Yu Jingyang Liu Ruijuan Liu Changgang Sun |
| author_facet | Chunjie Sun Hanyun Zhang Ye Li Yang Yu Jingyang Liu Ruijuan Liu Changgang Sun |
| author_sort | Chunjie Sun |
| collection | DOAJ |
| description | Background: Circadian rhythm is an internal timing system generated by circadian-related genes (CRGs). Disruption in this rhythm has been associated with a heightened risk of breast cancer (BC) and regulation of the immune microenvironment of tumors. This study aimed to investigate the clinical significance of CRGs in BC and the immune microenvironment. Methods: CRGs were identified using the GeneCards and MSigDB databases. Through unsupervised clustering, we identified two circadian-related subtypes in patients with BC. We constructed a prognostic model and nomogram for circadian-related risk scores using LASSO and Cox regression analyses. Using multi-omics analysis, the mutation profile and immunological microenvironment of tumors were investigated, and the immunotherapy response in different groups of patients was predicted based on their risk strata. Results: The two circadian-related subtypes of BC that were identified differed significantly in their prognoses, clinical characteristics, and tumor immune microenvironments. Subsequently, we constructed a circadian-related risk score (CRRS) model containing eight signatures (SIAH2, EZR, GSN, TAGLN2, PRDX1, MCM4, EIF4EBP1, and CD248) and a nomogram. High-risk individuals had a greater burden of tumor mutations, richer immune cell infiltration, and higher expression of immune checkpoint genes, than low-risk individuals, indicating a “hot tumor'' immune phenotype and a more favorable treatment outcome. Conclusions: Two circadian-related subtypes of BC were identified and used to establish a CRRS prognostic model and nomogram. These will be valuable in providing guidance for forecasting prognosis and developing personalized treatment plans for BC. |
| first_indexed | 2024-04-24T13:50:47Z |
| format | Article |
| id | doaj.art-bfb61f767e6842a8861311202e519de8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:50:47Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-bfb61f767e6842a8861311202e519de82024-04-04T05:04:41ZengElsevierHeliyon2405-84402024-03-01106e27356Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancerChunjie Sun0Hanyun Zhang1Ye Li2Yang Yu3Jingyang Liu4Ruijuan Liu5Changgang Sun6College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355 Shandong, ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355 Shandong, ChinaFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Taipa, 999078, ChinaFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Taipa, 999078, ChinaFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Taipa, 999078, ChinaDepartment of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041 Shandong, China; Corresponding author. Department of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041 Shandong, China.Department of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041 Shandong, China; College of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, 261053 Shandong, China; Corresponding author. Department of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041 Shandong, China. College of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, 261053 Shandong, China.Background: Circadian rhythm is an internal timing system generated by circadian-related genes (CRGs). Disruption in this rhythm has been associated with a heightened risk of breast cancer (BC) and regulation of the immune microenvironment of tumors. This study aimed to investigate the clinical significance of CRGs in BC and the immune microenvironment. Methods: CRGs were identified using the GeneCards and MSigDB databases. Through unsupervised clustering, we identified two circadian-related subtypes in patients with BC. We constructed a prognostic model and nomogram for circadian-related risk scores using LASSO and Cox regression analyses. Using multi-omics analysis, the mutation profile and immunological microenvironment of tumors were investigated, and the immunotherapy response in different groups of patients was predicted based on their risk strata. Results: The two circadian-related subtypes of BC that were identified differed significantly in their prognoses, clinical characteristics, and tumor immune microenvironments. Subsequently, we constructed a circadian-related risk score (CRRS) model containing eight signatures (SIAH2, EZR, GSN, TAGLN2, PRDX1, MCM4, EIF4EBP1, and CD248) and a nomogram. High-risk individuals had a greater burden of tumor mutations, richer immune cell infiltration, and higher expression of immune checkpoint genes, than low-risk individuals, indicating a “hot tumor'' immune phenotype and a more favorable treatment outcome. Conclusions: Two circadian-related subtypes of BC were identified and used to establish a CRRS prognostic model and nomogram. These will be valuable in providing guidance for forecasting prognosis and developing personalized treatment plans for BC.http://www.sciencedirect.com/science/article/pii/S2405844024033875Circadian rhythmCircadian-related genesBreast cancerTumor immune microenvironmentImmunotherapy |
| spellingShingle | Chunjie Sun Hanyun Zhang Ye Li Yang Yu Jingyang Liu Ruijuan Liu Changgang Sun Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer Heliyon Circadian rhythm Circadian-related genes Breast cancer Tumor immune microenvironment Immunotherapy |
| title | Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer |
| title_full | Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer |
| title_fullStr | Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer |
| title_full_unstemmed | Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer |
| title_short | Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer |
| title_sort | elucidation of clinical implications arising from circadian rhythm and insights into the tumor immune landscape in breast cancer |
| topic | Circadian rhythm Circadian-related genes Breast cancer Tumor immune microenvironment Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024033875 |
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