A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach
We present a microfluidic method to measure the elastic properties of a population of microcapsules (liquid drops enclosed by a thin hyperelastic membrane). The method is based on the observation of flowing capsules in a cylindrical capillary tube and an automatic inverse analysis of the deformed pr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2021-01-01
|
| Series: | Flow |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2633425921000088/type/journal_article |
| _version_ | 1811156331558600704 |
|---|---|
| author | Xing-Yi Wang Adlan Merlo Claire Dupont Anne-Virginie Salsac Dominique Barthès-Biesel |
| author_facet | Xing-Yi Wang Adlan Merlo Claire Dupont Anne-Virginie Salsac Dominique Barthès-Biesel |
| author_sort | Xing-Yi Wang |
| collection | DOAJ |
| description | We present a microfluidic method to measure the elastic properties of a population of microcapsules (liquid drops enclosed by a thin hyperelastic membrane). The method is based on the observation of flowing capsules in a cylindrical capillary tube and an automatic inverse analysis of the deformed profiles. The latter requires results from a full numerical model of the fluid–structure interaction accounting for nonlinear membrane elastic properties. For ease of use, we provide them under the form of databases, when the initially spherical capsule has a membrane governed by a neo-Hookean or a general Hooke's law with different surface Poisson ratios. Ultimately, the microfluidic method yields information on the type of elastic constitutive law that governs the capsule wall material together with the value of the elastic parameters. The method is applied to a population of ovalbumin microcapsules and is validated by means of independent experiments of the same capsules subjected to a different flow in a microrheological device. This is of great interest for quality control purposes, as small samples of capsule suspensions can be diverted to a measuring test section and mechanically tested with a 10 % precision using an automated process. |
| first_indexed | 2024-04-10T04:48:37Z |
| format | Article |
| id | doaj.art-bfb620ce104f406a844c9adb662d95eb |
| institution | Directory Open Access Journal |
| issn | 2633-4259 |
| language | English |
| last_indexed | 2024-04-10T04:48:37Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Flow |
| spelling | doaj.art-bfb620ce104f406a844c9adb662d95eb2023-03-09T12:34:16ZengCambridge University PressFlow2633-42592021-01-01110.1017/flo.2021.8A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approachXing-Yi Wang0Adlan Merlo1Claire Dupont2https://orcid.org/0000-0002-7727-3846Anne-Virginie Salsac3https://orcid.org/0000-0003-4677-8793Dominique Barthès-Biesel4https://orcid.org/0000-0001-7274-4752Biomechanics and Bioengineering Laboratory (UMR 7338), Université de Technologie de Compiègne – CNRS, CS 60319, 60203 Compiègne, FranceBiomechanics and Bioengineering Laboratory (UMR 7338), Université de Technologie de Compiègne – CNRS, CS 60319, 60203 Compiègne, FranceBiomechanics and Bioengineering Laboratory (UMR 7338), Université de Technologie de Compiègne – CNRS, CS 60319, 60203 Compiègne, FranceBiomechanics and Bioengineering Laboratory (UMR 7338), Université de Technologie de Compiègne – CNRS, CS 60319, 60203 Compiègne, FranceBiomechanics and Bioengineering Laboratory (UMR 7338), Université de Technologie de Compiègne – CNRS, CS 60319, 60203 Compiègne, FranceWe present a microfluidic method to measure the elastic properties of a population of microcapsules (liquid drops enclosed by a thin hyperelastic membrane). The method is based on the observation of flowing capsules in a cylindrical capillary tube and an automatic inverse analysis of the deformed profiles. The latter requires results from a full numerical model of the fluid–structure interaction accounting for nonlinear membrane elastic properties. For ease of use, we provide them under the form of databases, when the initially spherical capsule has a membrane governed by a neo-Hookean or a general Hooke's law with different surface Poisson ratios. Ultimately, the microfluidic method yields information on the type of elastic constitutive law that governs the capsule wall material together with the value of the elastic parameters. The method is applied to a population of ovalbumin microcapsules and is validated by means of independent experiments of the same capsules subjected to a different flow in a microrheological device. This is of great interest for quality control purposes, as small samples of capsule suspensions can be diverted to a measuring test section and mechanically tested with a 10 % precision using an automated process.https://www.cambridge.org/core/product/identifier/S2633425921000088/type/journal_articleCapsule/cell dynamicsRheological measurementsFluid–structure interaction modellingMechanical identification |
| spellingShingle | Xing-Yi Wang Adlan Merlo Claire Dupont Anne-Virginie Salsac Dominique Barthès-Biesel A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach Flow Capsule/cell dynamics Rheological measurements Fluid–structure interaction modelling Mechanical identification |
| title | A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach |
| title_full | A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach |
| title_fullStr | A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach |
| title_full_unstemmed | A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach |
| title_short | A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach |
| title_sort | microfluidic methodology to identify the mechanical properties of capsules comparison with a microrheometric approach |
| topic | Capsule/cell dynamics Rheological measurements Fluid–structure interaction modelling Mechanical identification |
| url | https://www.cambridge.org/core/product/identifier/S2633425921000088/type/journal_article |
| work_keys_str_mv | AT xingyiwang amicrofluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT adlanmerlo amicrofluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT clairedupont amicrofluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT annevirginiesalsac amicrofluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT dominiquebarthesbiesel amicrofluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT xingyiwang microfluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT adlanmerlo microfluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT clairedupont microfluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT annevirginiesalsac microfluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach AT dominiquebarthesbiesel microfluidicmethodologytoidentifythemechanicalpropertiesofcapsulescomparisonwithamicrorheometricapproach |