Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop
Abstract Extracellular vesicles (EVs) large‐scale production is a crucial point for the translation of EVs from discovery to application of EV‐based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET‐OPEN projects, “The Extracellular...
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Journal of Extracellular Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jex2.63 |
| _version_ | 1797767012704845824 |
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| author | Lucia Paolini Marta Monguió‐Tortajada Marta Costa Fabio Antenucci Mario Barilani Marta Clos‐Sansalvador André Cronemberger Andrade Tom A. P. Driedonks Sara Giancaterino Stephanie M. Kronstadt Rachel R. Mizenko Muhammad Nawaz Xabier Osteikoetxea Carla Pereira Surya Shrivastava Anders Toftegaard Boysen Simonides Immanuel van deWakker Martijn J. C. vanHerwijnen Xiaoqin Wang Dionysios C. Watson Mario Gimona Maria Kaparakis‐Liaskos Konstantin Konstantinov Sai Kiang Lim Nicole Meisner‐Kober Michiel Stork Peter Nejsum Annalisa Radeghieri Eva Rohde Nicolas Touzet Marca H. M. Wauben Kenneth W. Witwer Antonella Bongiovanni Paolo Bergese |
| author_facet | Lucia Paolini Marta Monguió‐Tortajada Marta Costa Fabio Antenucci Mario Barilani Marta Clos‐Sansalvador André Cronemberger Andrade Tom A. P. Driedonks Sara Giancaterino Stephanie M. Kronstadt Rachel R. Mizenko Muhammad Nawaz Xabier Osteikoetxea Carla Pereira Surya Shrivastava Anders Toftegaard Boysen Simonides Immanuel van deWakker Martijn J. C. vanHerwijnen Xiaoqin Wang Dionysios C. Watson Mario Gimona Maria Kaparakis‐Liaskos Konstantin Konstantinov Sai Kiang Lim Nicole Meisner‐Kober Michiel Stork Peter Nejsum Annalisa Radeghieri Eva Rohde Nicolas Touzet Marca H. M. Wauben Kenneth W. Witwer Antonella Bongiovanni Paolo Bergese |
| author_sort | Lucia Paolini |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) large‐scale production is a crucial point for the translation of EVs from discovery to application of EV‐based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET‐OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor‐made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV‐based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field. |
| first_indexed | 2024-03-12T20:32:35Z |
| format | Article |
| id | doaj.art-bfb6a9eefc6c4b619c546518b118b87a |
| institution | Directory Open Access Journal |
| issn | 2768-2811 |
| language | English |
| last_indexed | 2024-03-12T20:32:35Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Biology |
| spelling | doaj.art-bfb6a9eefc6c4b619c546518b118b87a2023-08-01T18:56:02ZengWileyJournal of Extracellular Biology2768-28112022-10-01110n/an/a10.1002/jex2.63Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshopLucia Paolini0Marta Monguió‐Tortajada1Marta Costa2Fabio Antenucci3Mario Barilani4Marta Clos‐Sansalvador5André Cronemberger Andrade6Tom A. P. Driedonks7Sara Giancaterino8Stephanie M. Kronstadt9Rachel R. Mizenko10Muhammad Nawaz11Xabier Osteikoetxea12Carla Pereira13Surya Shrivastava14Anders Toftegaard Boysen15Simonides Immanuel van deWakker16Martijn J. C. vanHerwijnen17Xiaoqin Wang18Dionysios C. Watson19Mario Gimona20Maria Kaparakis‐Liaskos21Konstantin Konstantinov22Sai Kiang Lim23Nicole Meisner‐Kober24Michiel Stork25Peter Nejsum26Annalisa Radeghieri27Eva Rohde28Nicolas Touzet29Marca H. M. Wauben30Kenneth W. Witwer31Antonella Bongiovanni32Paolo Bergese33Department of Molecular and Translational Medicine University of Brescia Brescia ItalyCREC Research Program Health Science Research Institute Germans Trias i Pujol (IGTP) Badalona SpainiBET Instituto de Biologia Experimental e Tecnológica Oeiras PortugalDepartment of Veterinary and Animal Sciences University of Copenhagen Copenhagen DenmarkLaboratory of Regenerative Medicine ‒ Cell Factory Department of Transfusion Medicine and Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano ItalyREMAR‐IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department University Hospital Germans Trias i Pujol (HUGTiP) Badalona (Barcelona) Catalonia SpainExperimental and Clinical Cell Therapy Institute (ExCT) Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University Salzburg AustriaCDL Research University Medical Center Utrecht Utrecht University Utrecht The NetherlandsDepartment of Civil Chemical Environmental and Materials Engineering Alma Mater Studiorum University of Bologna Bologna ItalyFischell Department of Bioengineering University of Maryland College Park Maryland USADepartment of Biomedical Engineering University of California Davis California USADepartment of Rheumatology and Inflammation Research Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg SwedenHCEMM‐SU Extracellular Vesicles Research Group Budapest HungaryExogenus Therapeutics S.A. Cantanhede PortugalCenter for Gene Therapy City of Hope Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute at the City of Hope Duarte California USADepartment of Clinical Medicine Aarhus University Aarhus DenmarkDepartment of Cardiology Experimental Cardiology Laboratory University Medical Center Utrecht Utrecht University Utrecht The NetherlandsDepartment of Biomolecular Health Sciences Faculty of Veterinary Medicine Utrecht University Utrecht NetherlandsDiscovery Biology Discovery Sciences BioPharmaceuticals R&D AstraZeneca Gothenburg SwedenUniversity Hospitals Cleveland Medical Center Cleveland Ohio USAGMP Unit Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI‐TReCS) Paracelsus Medical University Salzburg AustriaDepartment of Microbiology, Anatomy, Physiology and Pharmacology La Trobe University Melbourne Victoria AustraliaCodiak BioSciences Cambridge Massachusetts USAExosome and Secreted Nano‐vesicle Institute of Molecular & Cell Biology Singapore SingaporeDepartment of Biosciences and Medical Biology Paris‐Lodron University Salzburg Hellbrunnerstrasse 34 Salzburg AustriaIntravacc Bilthoven The NetherlandsDepartment of Clinical Medicine Aarhus University Aarhus DenmarkDepartment of Molecular and Translational Medicine University of Brescia Brescia ItalyGMP Unit Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI‐TReCS) Paracelsus Medical University Salzburg AustriaCentre for Environmental Research Innovation and Sustainability Institute of Technology Sligo Sligo IrelandDepartment of Biomolecular Health Sciences Faculty of Veterinary Medicine Utrecht University Utrecht NetherlandsDepartment of Molecular and Comparative Pathology Johns Hopkins School of Medicine Baltimore Maryland USACell‐Tech HUB and Institute for Research and Biomedical Innovation National Research Council of Italy (CNR) Palermo ItalyDepartment of Molecular and Translational Medicine University of Brescia Brescia ItalyAbstract Extracellular vesicles (EVs) large‐scale production is a crucial point for the translation of EVs from discovery to application of EV‐based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET‐OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor‐made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV‐based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.https://doi.org/10.1002/jex2.63EV‐based productsextracellular vesiclesISEV workshoplarge‐scale productionmanufacturingprocessing |
| spellingShingle | Lucia Paolini Marta Monguió‐Tortajada Marta Costa Fabio Antenucci Mario Barilani Marta Clos‐Sansalvador André Cronemberger Andrade Tom A. P. Driedonks Sara Giancaterino Stephanie M. Kronstadt Rachel R. Mizenko Muhammad Nawaz Xabier Osteikoetxea Carla Pereira Surya Shrivastava Anders Toftegaard Boysen Simonides Immanuel van deWakker Martijn J. C. vanHerwijnen Xiaoqin Wang Dionysios C. Watson Mario Gimona Maria Kaparakis‐Liaskos Konstantin Konstantinov Sai Kiang Lim Nicole Meisner‐Kober Michiel Stork Peter Nejsum Annalisa Radeghieri Eva Rohde Nicolas Touzet Marca H. M. Wauben Kenneth W. Witwer Antonella Bongiovanni Paolo Bergese Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop Journal of Extracellular Biology EV‐based products extracellular vesicles ISEV workshop large‐scale production manufacturing processing |
| title | Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop |
| title_full | Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop |
| title_fullStr | Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop |
| title_full_unstemmed | Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop |
| title_short | Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop |
| title_sort | large scale production of extracellular vesicles report on the massivevs isev workshop |
| topic | EV‐based products extracellular vesicles ISEV workshop large‐scale production manufacturing processing |
| url | https://doi.org/10.1002/jex2.63 |
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