Production of Prodiginines Is Part of a Programmed Cell Death Process in Streptomyces coelicolor

Production of Prodiginines Is Part of a Programmed Cell Death Process in Streptomyces coelicolor

Actinobacteria are prolific producers of antitumor antibiotics with antiproliferative activity, but why these bacteria synthetize metabolites with this bioactivity has so far remained a mystery. In this work we raised the hypothesis that under certain circumstances, production of antiproliferative a...

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Bibliographic Details
Main Authors: Elodie Tenconi, Matthew F. Traxler, Charline Hoebreck, Gilles P. van Wezel, Sébastien Rigali
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
antitumor antibiotics
secondary metabolites
DNA-damaging agents
cell death and differentiation
bacterial development
confocal laser microscopy
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01742/full

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