Second generation inactivated eastern equine encephalitis virus vaccine candidates protect mice against a lethal aerosol challenge.

Second generation inactivated eastern equine encephalitis virus vaccine candidates protect mice against a lethal aerosol challenge.

Currently, there are no FDA-licensed vaccines or therapeutics for eastern equine encephalitis virus (EEEV) for human use. We recently developed several methods to inactivate CVEV1219, a chimeric live-attenuated eastern equine encephalitis virus (EEEV). Dosage and schedule studies were conducted to e...

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Bibliographic Details
Main Authors: Shelley P Honnold, Russell R Bakken, Diana Fisher, Cathleen M Lind, Jeffrey W Cohen, Lori T Eccleston, Kevin B Spurgers, Radha K Maheshwari, Pamela J Glass
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4130539?pdf=render

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