ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY
ABSTRACT: Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222000121 |
| _version_ | 1818329774215397376 |
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| author | Norliana Ismail Noraryana Hassan Muhammad Hairul Nizam Abd Hamid Ummi Nadiah Yusoff Noor Raihan Khamal Mohd Azahadi Omar Xin Ci Wong Mohan Dass Pathmanathan Shahanizan Mohd Zin Faizah Muhammad Zin Mohamad Haniki Nik Mohamed Norashidah Mohd Nor |
| author_facet | Norliana Ismail Noraryana Hassan Muhammad Hairul Nizam Abd Hamid Ummi Nadiah Yusoff Noor Raihan Khamal Mohd Azahadi Omar Xin Ci Wong Mohan Dass Pathmanathan Shahanizan Mohd Zin Faizah Muhammad Zin Mohamad Haniki Nik Mohamed Norashidah Mohd Nor |
| author_sort | Norliana Ismail |
| collection | DOAJ |
| description | ABSTRACT: Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status. Results: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups. Conclusion: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection. |
| first_indexed | 2024-12-13T12:53:24Z |
| format | Article |
| id | doaj.art-bfbca78dd9ae4c95aa01f9068504e58a |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T12:53:24Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-bfbca78dd9ae4c95aa01f9068504e58a2022-12-21T23:45:15ZengElsevierInternational Journal of Infectious Diseases1201-97122022-03-01116189196ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDYNorliana Ismail0Noraryana Hassan1Muhammad Hairul Nizam Abd Hamid2Ummi Nadiah Yusoff3Noor Raihan Khamal4Mohd Azahadi Omar5Xin Ci Wong6Mohan Dass Pathmanathan7Shahanizan Mohd Zin8Faizah Muhammad Zin9Mohamad Haniki Nik Mohamed10Norashidah Mohd Nor11Disease Control Division, Ministry of Health, Malaysia; Corresponding authors:Disease Control Division, Ministry of Health, Malaysia; Corresponding authors:Disease Control Division, Ministry of Health, MalaysiaDisease Control Division, Ministry of Health, MalaysiaDisease Control Division, Ministry of Health, MalaysiaNational Institute of Health, Ministry of Health, MalaysiaDigital Health Research and Innovation Unit, Institute for Clinical Research, MalaysiaDigital Health Research and Innovation Unit, Institute for Clinical Research, MalaysiaMedical Division, Ministry of Health, MalaysiaMedical Division, Ministry of Health, MalaysiaKulliyyah of Pharmacy, International Islamic University of Malaysia (Chairman of Technical Working Group World Health Organization Framework Convention on Tobacco Control Malaysia)Faculty of Economy, University Putra Malaysia (Vice Chairman of Technical Working Group World Health Organization Framework Convention on Tobacco Control Malaysia)ABSTRACT: Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status. Results: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups. Conclusion: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection.http://www.sciencedirect.com/science/article/pii/S1201971222000121SmokingCOVID-19severitycomplicationsdisease outcomeMalaysia |
| spellingShingle | Norliana Ismail Noraryana Hassan Muhammad Hairul Nizam Abd Hamid Ummi Nadiah Yusoff Noor Raihan Khamal Mohd Azahadi Omar Xin Ci Wong Mohan Dass Pathmanathan Shahanizan Mohd Zin Faizah Muhammad Zin Mohamad Haniki Nik Mohamed Norashidah Mohd Nor ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY International Journal of Infectious Diseases Smoking COVID-19 severity complications disease outcome Malaysia |
| title | ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY |
| title_full | ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY |
| title_fullStr | ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY |
| title_full_unstemmed | ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY |
| title_short | ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY |
| title_sort | association of smoking and severity of covid 19 infection among 5 889 patients in malaysia a multi center observational study |
| topic | Smoking COVID-19 severity complications disease outcome Malaysia |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222000121 |
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