Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks
Background: During the last decade, intra-spinal micro-stimulation (ISMS) has been proposed as a potential technique for restoring the motor function in paralyzed limbs. It has been shown that there are functional networks of inter-neurons in the spinal cord (i.e., movement primitive block or motor...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2013-10-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/2330 |
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| author | Alireza Asadi Abbas Erfanian Omidvar |
| author_facet | Alireza Asadi Abbas Erfanian Omidvar |
| author_sort | Alireza Asadi |
| collection | DOAJ |
| description | Background: During the last decade, intra-spinal micro-stimulation (ISMS) has been proposed as a potential technique for restoring the motor function in paralyzed limbs. It has been shown that there are functional networks of inter-neurons in the spinal cord (i.e., movement primitive block or motor module) that generate particular motor outputs by selecting specific patterns of muscles activation. In this paper, we investigated the possible activation of the motor module via intra-spinal micro-stimulation.
Methods: The experiments were conducted on three adult female Wistar rats. A partial laminectomy was performed to expose at the T13-L4 level. The animals were positioned in a stereotaxic setup which allowed the hindlimbs to hang free while the head and spinal vertebrae (T12 and L5) were clamped rigidly to the frame. We developed custom made real-time software written in LabVIEW to estimate the joint angles. To stimulate the spinal cord, a computer-based sixteen-channel stimulator was used. The amplitude, pulse width and frequency of the stimulation signal could be varied online. Different positions within the spinal cord between the T13-L4 regions were stimulated and the joint angles were measured.
Findings: Movement primitive blocks associated with stepping could be generated using ISMS. Recruitment curves of the motor primitive blocks showed liner relationship between stimulation signal and joint angles. By defining a specific pattern of motor primitives' activation, the locomotor-like stepping could be generated.
Conclusion: The complex locomotor-like stepping can be generated by the combination of the motor primitives using ISMS. |
| first_indexed | 2024-03-12T09:03:00Z |
| format | Article |
| id | doaj.art-bfbd54511baa40c1b7c7cd0a68ec20d5 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:03:00Z |
| publishDate | 2013-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-bfbd54511baa40c1b7c7cd0a68ec20d52023-09-02T15:30:09ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2013-10-0131250132413381406Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive BlocksAlireza Asadi0Abbas Erfanian Omidvar1PhD Candidate, Iran Neural Technology Research Center AND Department of Biomedical Engineering, School of Electrical Engineering, Iran University of Science and Technology, Tehran, IranProfessor, Iran Neural Technology Research Center AND Department of Biomedical Engineering, School of Electrical Engineering, Iran University of Science and Technology, Tehran, IranBackground: During the last decade, intra-spinal micro-stimulation (ISMS) has been proposed as a potential technique for restoring the motor function in paralyzed limbs. It has been shown that there are functional networks of inter-neurons in the spinal cord (i.e., movement primitive block or motor module) that generate particular motor outputs by selecting specific patterns of muscles activation. In this paper, we investigated the possible activation of the motor module via intra-spinal micro-stimulation. Methods: The experiments were conducted on three adult female Wistar rats. A partial laminectomy was performed to expose at the T13-L4 level. The animals were positioned in a stereotaxic setup which allowed the hindlimbs to hang free while the head and spinal vertebrae (T12 and L5) were clamped rigidly to the frame. We developed custom made real-time software written in LabVIEW to estimate the joint angles. To stimulate the spinal cord, a computer-based sixteen-channel stimulator was used. The amplitude, pulse width and frequency of the stimulation signal could be varied online. Different positions within the spinal cord between the T13-L4 regions were stimulated and the joint angles were measured. Findings: Movement primitive blocks associated with stepping could be generated using ISMS. Recruitment curves of the motor primitive blocks showed liner relationship between stimulation signal and joint angles. By defining a specific pattern of motor primitives' activation, the locomotor-like stepping could be generated. Conclusion: The complex locomotor-like stepping can be generated by the combination of the motor primitives using ISMS.http://jims.mui.ac.ir/index.php/jims/article/view/2330Functional electrical stimulationIntraspinal microstimulationIintra-spinal micro-stimulation (ISMS)Movement primitive blocksRecruitment curveStep-like movement |
| spellingShingle | Alireza Asadi Abbas Erfanian Omidvar Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks مجله دانشکده پزشکی اصفهان Functional electrical stimulation Intraspinal microstimulation Iintra-spinal micro-stimulation (ISMS) Movement primitive blocks Recruitment curve Step-like movement |
| title | Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks |
| title_full | Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks |
| title_fullStr | Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks |
| title_full_unstemmed | Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks |
| title_short | Restoring the Stepping-Like Movement in Spinal Rat by Electrical Micro-Stimulation of Motor Primitive Blocks |
| title_sort | restoring the stepping like movement in spinal rat by electrical micro stimulation of motor primitive blocks |
| topic | Functional electrical stimulation Intraspinal microstimulation Iintra-spinal micro-stimulation (ISMS) Movement primitive blocks Recruitment curve Step-like movement |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/2330 |
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