Cardiac immune cell infiltration associates with abnormal lipid metabolism

Cardiac immune cell infiltration associates with abnormal lipid metabolism

CD36 mediates the uptake of long-chain fatty acids (FAs), a major energy substrate for the myocardium. Under excessive FA supply, CD36 can cause cardiac lipid accumulation and inflammation while its deletion reduces heart FA uptake and lipid content and increases glucose utilization. As a result, CD...

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Bibliographic Details
Main Authors: Vincenza Cifarelli, Ondrej Kuda, Kui Yang, Xinping Liu, Richard W. Gross, Terri A. Pietka, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Josie Lesser, Morgan Ross, Ira J. Goldberg, Robert J. Gropler, Yongjian Liu, Nada A. Abumrad
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
CD36
PET tracers
cardiac inflammation
lipidomics
eicosanoids
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.948332/full

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