Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial
Background Bipolar disorder is a source of marked disability, morbidity and premature death. There is a paucity of research on personalised psychosocial interventions for bipolar disorder, especially in low-resource settings. A pilot randomised controlled trial (RCT) of a culturally adapted psychoed...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-11-01
|
| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472422005981/type/journal_article |
| _version_ | 1811156876568559616 |
|---|---|
| author | M. Ishrat Husain Madeha Umer Muqaddas Asif Ameer B. Khoso Tayyeba Kiran Moin Ansari Huma Aslam Moti Ram Bhatia Farasat A. Dogar M. Omair Husain Hazrat A. Khan Ali A. Mufti Benoit H. Mulsant Farooq Naeem Haider A. Naqvi Claire de Oliveira M. Sajjad Siddiqui Asad Tamizuddin Wei Wang Juveria Zaheer Nusrat Husain Nasim Chaudhry Imran B. Chaudhry |
| author_facet | M. Ishrat Husain Madeha Umer Muqaddas Asif Ameer B. Khoso Tayyeba Kiran Moin Ansari Huma Aslam Moti Ram Bhatia Farasat A. Dogar M. Omair Husain Hazrat A. Khan Ali A. Mufti Benoit H. Mulsant Farooq Naeem Haider A. Naqvi Claire de Oliveira M. Sajjad Siddiqui Asad Tamizuddin Wei Wang Juveria Zaheer Nusrat Husain Nasim Chaudhry Imran B. Chaudhry |
| author_sort | M. Ishrat Husain |
| collection | DOAJ |
| description | Background
Bipolar disorder is a source of marked disability, morbidity and premature death. There is a paucity of research on personalised psychosocial interventions for bipolar disorder, especially in low-resource settings. A pilot randomised controlled trial (RCT) of a culturally adapted psychoeducation intervention for bipolar disorder (CaPE) in Pakistan reported higher patient satisfaction, enhanced medication adherence, knowledge and attitudes regarding bipolar disorder, and improvement in mood symptom scores and health-related quality of life measures compared with treatment as usual (TAU).
Aims
The current protocol describes a larger multicentre RCT to confirm the clinical and cost-effectiveness of CaPE in Pakistan. Trial registration: NCT05223959.
Method
A multicentre individual, parallel-arm RCT of CaPE in 300 Pakistani adults with bipolar disorder. Participants over the age of 18, with a diagnosis of bipolar I or II disorder who are currently euthymic, will be recruited from seven sites: Karachi, Lahore, Multan, Rawalpindi, Peshawar, Hyderabad and Quetta. Time to recurrence will be the primary outcome assessed using the Longitudinal Interval Follow-up Evaluation (LIFE). Secondary measures will include mood symptoms, quality of life and functioning, adherence to psychotropic medications, and knowledge and attitudes regarding bipolar disorder.
Results
This trial will assess the effectiveness of the CaPE intervention compared with TAU in reducing the time to recurrence for people with bipolar disorder currently in remission in Pakistan and determine the effect on clinical outcomes, quality of life and functioning.
Conclusions
A successful trial might lead to rapid implementation of CaPE in clinical practice, not only in Pakistan, but also in other low-resource settings, including those in high-income countries, to improve clinical outcomes, social and occupational functioning, and quality of life in South Asian and other minority group patients with bipolar disorder.
|
| first_indexed | 2024-04-10T04:58:22Z |
| format | Article |
| id | doaj.art-bfbe11feca3f4cf2a1d07fe388e1c758 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:58:22Z |
| publishDate | 2022-11-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-bfbe11feca3f4cf2a1d07fe388e1c7582023-03-09T12:29:24ZengCambridge University PressBJPsych Open2056-47242022-11-01810.1192/bjo.2022.598Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trialM. Ishrat Husain0Madeha Umer1https://orcid.org/0000-0003-0958-1211Muqaddas Asif2Ameer B. Khoso3Tayyeba Kiran4https://orcid.org/0000-0003-2478-4148Moin Ansari5Huma Aslam6Moti Ram Bhatia7Farasat A. Dogar8M. Omair Husain9https://orcid.org/0000-0002-8575-3364Hazrat A. Khan10Ali A. Mufti11Benoit H. Mulsant12Farooq Naeem13Haider A. Naqvi14Claire de Oliveira15https://orcid.org/0000-0003-3961-6008M. Sajjad Siddiqui16Asad Tamizuddin17Wei Wang18Juveria Zaheer19https://orcid.org/0000-0001-5071-8078Nusrat Husain20Nasim Chaudhry21https://orcid.org/0000-0003-4142-868XImran B. Chaudhry22Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Pakistan Institute of Living and Learning, Karachi, PakistanPakistan Institute of Living and Learning, Karachi, PakistanPakistan Institute of Living and Learning, Karachi, PakistanPakistan Institute of Living and Learning, Karachi, PakistanDepartment of Psychiatry, Liaquat University of Medical and Health Sciences, Hyderabad, PakistanDepartment of Psychiatry and Behavioral Sciences, Allama Iqbal Medical College/Jinnah Hospital, Lahore, PakistanDepartment of Psychiatry, Peoples University of Medical and Health Sciences for Women, Nawabshah-Shaheed Benazirabad, PakistanPunjab Institute of Mental Health, Lahore, PakistanCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaBalochistan Institute of Psychiatry and Behavioral Sciences, Quetta, PakistanJinnah Medical College, Peshawar, PakistanCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaDepartment of Psychiatry, DOW University of Health Sciences, Karachi, PakistanCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaNational Psychiatric Hospital, Multan, PakistanInstitute of Psychiatry, WHO Collaborating Centre for Mental Health Research and Training, Rawalpindi, PakistanCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK; and Mersey Care NHS Foundation Trust, Liverpool, UKPakistan Institute of Living and Learning, Karachi, PakistanPakistan Institute of Living and Learning, Karachi, Pakistan; Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK; and Department of Psychiatry, Ziauddin University, Karachi, PakistanBackground Bipolar disorder is a source of marked disability, morbidity and premature death. There is a paucity of research on personalised psychosocial interventions for bipolar disorder, especially in low-resource settings. A pilot randomised controlled trial (RCT) of a culturally adapted psychoeducation intervention for bipolar disorder (CaPE) in Pakistan reported higher patient satisfaction, enhanced medication adherence, knowledge and attitudes regarding bipolar disorder, and improvement in mood symptom scores and health-related quality of life measures compared with treatment as usual (TAU). Aims The current protocol describes a larger multicentre RCT to confirm the clinical and cost-effectiveness of CaPE in Pakistan. Trial registration: NCT05223959. Method A multicentre individual, parallel-arm RCT of CaPE in 300 Pakistani adults with bipolar disorder. Participants over the age of 18, with a diagnosis of bipolar I or II disorder who are currently euthymic, will be recruited from seven sites: Karachi, Lahore, Multan, Rawalpindi, Peshawar, Hyderabad and Quetta. Time to recurrence will be the primary outcome assessed using the Longitudinal Interval Follow-up Evaluation (LIFE). Secondary measures will include mood symptoms, quality of life and functioning, adherence to psychotropic medications, and knowledge and attitudes regarding bipolar disorder. Results This trial will assess the effectiveness of the CaPE intervention compared with TAU in reducing the time to recurrence for people with bipolar disorder currently in remission in Pakistan and determine the effect on clinical outcomes, quality of life and functioning. Conclusions A successful trial might lead to rapid implementation of CaPE in clinical practice, not only in Pakistan, but also in other low-resource settings, including those in high-income countries, to improve clinical outcomes, social and occupational functioning, and quality of life in South Asian and other minority group patients with bipolar disorder. https://www.cambridge.org/core/product/identifier/S2056472422005981/type/journal_articleBipolar disorderpsychoeducationclinical trialPakistanpsychosocial interventions |
| spellingShingle | M. Ishrat Husain Madeha Umer Muqaddas Asif Ameer B. Khoso Tayyeba Kiran Moin Ansari Huma Aslam Moti Ram Bhatia Farasat A. Dogar M. Omair Husain Hazrat A. Khan Ali A. Mufti Benoit H. Mulsant Farooq Naeem Haider A. Naqvi Claire de Oliveira M. Sajjad Siddiqui Asad Tamizuddin Wei Wang Juveria Zaheer Nusrat Husain Nasim Chaudhry Imran B. Chaudhry Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial BJPsych Open Bipolar disorder psychoeducation clinical trial Pakistan psychosocial interventions |
| title | Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial |
| title_full | Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial |
| title_fullStr | Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial |
| title_full_unstemmed | Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial |
| title_short | Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomised controlled trial |
| title_sort | culturally adapted psychoeducation for bipolar disorder in a low resource setting protocol for a multicentre randomised controlled trial |
| topic | Bipolar disorder psychoeducation clinical trial Pakistan psychosocial interventions |
| url | https://www.cambridge.org/core/product/identifier/S2056472422005981/type/journal_article |
| work_keys_str_mv | AT mishrathusain culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT madehaumer culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT muqaddasasif culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT ameerbkhoso culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT tayyebakiran culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT moinansari culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT humaaslam culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT motirambhatia culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT farasatadogar culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT momairhusain culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT hazratakhan culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT aliamufti culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT benoithmulsant culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT farooqnaeem culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT haideranaqvi culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT clairedeoliveira culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT msajjadsiddiqui culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT asadtamizuddin culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT weiwang culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT juveriazaheer culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT nusrathusain culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT nasimchaudhry culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial AT imranbchaudhry culturallyadaptedpsychoeducationforbipolardisorderinalowresourcesettingprotocolforamulticentrerandomisedcontrolledtrial |