Discovery and Characterization of an Aberrant Small Form of Glycoprotein I of Herpes Simplex Virus Type I in Cell Culture

Discovery and Characterization of an Aberrant Small Form of Glycoprotein I of Herpes Simplex Virus Type I in Cell Culture

ABSTRACT The 380-to-393-amino-acid glycoprotein I (gI) encoded by herpes simplex virus 1 (HSV-1) is a critical mediator for viral cell-to-cell spread and syncytium formation. Here we report a previously unrecognized aberrant form of gI in HSV-1-infected cells. Production of this molecule is independ...

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Bibliographic Details
Main Authors: Xixi Gui, Wuchao Zhang, Peng Gao, Yongning Zhang, Lei Zhou, Xinna Ge, Xin Guo, John W. Wills, Jun Han, Hanchun Yang
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
aberrant gel migration
cell-to-cell spread
cell-cell fusion
glycoprotein I
herpes simplex virus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02659-21

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