X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia
Abstract An approximately 1‐year‐old male intact Shih Tzu dog was referred to a tertiary facility with a history of progressive tachypnea, increased respiratory effort, and weight loss over a 3‐month period that failed to improve with empirical antimicrobial treatment. Upon completion of a comprehen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15988 |
| _version_ | 1798030143409618944 |
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| author | Kristen Merrill Emily Coffey Eva Furrow Isabelle Masseau Hansjörg Rindt Carol Reinero |
| author_facet | Kristen Merrill Emily Coffey Eva Furrow Isabelle Masseau Hansjörg Rindt Carol Reinero |
| author_sort | Kristen Merrill |
| collection | DOAJ |
| description | Abstract An approximately 1‐year‐old male intact Shih Tzu dog was referred to a tertiary facility with a history of progressive tachypnea, increased respiratory effort, and weight loss over a 3‐month period that failed to improve with empirical antimicrobial treatment. Upon completion of a comprehensive respiratory evaluation, the dog was diagnosed with severe Pneumocystis pneumonia and secondary pulmonary hypertension. Clinical signs resolved and disease resolution was confirmed after completion of an 8‐week course of trimethoprim‐sulfonamide, 4‐week tapering dose of prednisone to decrease an inflammatory response secondary to acute die‐off of organisms, a 2‐week course of clopidogrel to prevent clot formation, and a 2‐week course of a phosphodiesterase‐5 inhibitor to treat pulmonary hypertension. Immunodiagnostic testing and genetic sequencing were performed to evaluate for potential immunodeficiency as an underlying cause for the development Pneumocystis pneumonia, and identified an X‐linked CD40 ligand deficiency. |
| first_indexed | 2024-04-11T19:36:37Z |
| format | Article |
| id | doaj.art-bfc2faf2661641d5b293cc37d6beade1 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T19:36:37Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-bfc2faf2661641d5b293cc37d6beade12022-12-22T04:06:51ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-01-0135149750310.1111/jvim.15988X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumoniaKristen Merrill0Emily Coffey1Eva Furrow2Isabelle Masseau3Hansjörg Rindt4Carol Reinero5Department of Veterinary Medicine and Surgery University of Missouri, Ringgold Standard Institution ‐ Small Animal Internal Medicine Columbia Missouri USAUniversity of Minnesota, Ringgold Standard Institution Minneapolis Minnesota USAUniversity of Minnesota, Internal Medicine Veterinary Medical Center St. Paul Minnesota USADepartment of Sciences Cliniques Universite de Montreal St. Hyacinthe Quebec CanadaUniversity of Missouri, College of Veterinary Medicine, Veterinary Medicine and Surgery Columbia Missouri USAUniversity of Missouri, Veterinary Medicine and Surgery Columbia Missouri USAAbstract An approximately 1‐year‐old male intact Shih Tzu dog was referred to a tertiary facility with a history of progressive tachypnea, increased respiratory effort, and weight loss over a 3‐month period that failed to improve with empirical antimicrobial treatment. Upon completion of a comprehensive respiratory evaluation, the dog was diagnosed with severe Pneumocystis pneumonia and secondary pulmonary hypertension. Clinical signs resolved and disease resolution was confirmed after completion of an 8‐week course of trimethoprim‐sulfonamide, 4‐week tapering dose of prednisone to decrease an inflammatory response secondary to acute die‐off of organisms, a 2‐week course of clopidogrel to prevent clot formation, and a 2‐week course of a phosphodiesterase‐5 inhibitor to treat pulmonary hypertension. Immunodiagnostic testing and genetic sequencing were performed to evaluate for potential immunodeficiency as an underlying cause for the development Pneumocystis pneumonia, and identified an X‐linked CD40 ligand deficiency.https://doi.org/10.1111/jvim.15988gene mappinggenetic markersimmunodeficiencyinfectious diseasespneumoniathoracic imaging |
| spellingShingle | Kristen Merrill Emily Coffey Eva Furrow Isabelle Masseau Hansjörg Rindt Carol Reinero X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia Journal of Veterinary Internal Medicine gene mapping genetic markers immunodeficiency infectious diseases pneumonia thoracic imaging |
| title | X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia |
| title_full | X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia |
| title_fullStr | X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia |
| title_full_unstemmed | X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia |
| title_short | X‐linked CD40 ligand deficiency in a 1‐year‐old male Shih Tzu with secondary Pneumocystis pneumonia |
| title_sort | x linked cd40 ligand deficiency in a 1 year old male shih tzu with secondary pneumocystis pneumonia |
| topic | gene mapping genetic markers immunodeficiency infectious diseases pneumonia thoracic imaging |
| url | https://doi.org/10.1111/jvim.15988 |
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