Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor. We have developed a broadly neutralizing antibod...

Полное описание

Библиографические подробности
Главные авторы:	Bo-Seong Jeong, Joon Young Jeon, Chih-Jen Lai, Hye-Yeoung Yun, Jae U. Jung, Byung-Ha Oh
Формат:	Статья
Язык:	English
Опубликовано:	Frontiers Media S.A. 2022-11-01
Серии:	Frontiers in Immunology
Предметы:	SARS-CoV-2 viral evolution key epitope computational affinity maturation broadly neutralizing antibody broad-spectrum vaccine
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049867/full

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