The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report
Background: Patients with lipoprotein lipase (LPL) deficiency, an inherited disorder, develop hypertriglyceridemia, which can lead to recurrent pancreatitis. The mainstay of therapy is medical nutritional therapy. Case Report: We present the case of a 35-year-old woman with LPL deficiency who experi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | AACE Clinical Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S237606052100122X |
| _version_ | 1828735029921972224 |
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| author | Zachary S. Jarrett, DO Chung-ting J. Kou, DO WingYee Wan, MD Jeffery A. Colburn, MD |
| author_facet | Zachary S. Jarrett, DO Chung-ting J. Kou, DO WingYee Wan, MD Jeffery A. Colburn, MD |
| author_sort | Zachary S. Jarrett, DO |
| collection | DOAJ |
| description | Background: Patients with lipoprotein lipase (LPL) deficiency, an inherited disorder, develop hypertriglyceridemia, which can lead to recurrent pancreatitis. The mainstay of therapy is medical nutritional therapy. Case Report: We present the case of a 35-year-old woman with LPL deficiency who experienced recurrent hospitalizations for hypertriglyceridemia-induced pancreatitis, which was effectively treated with orlistat. Discussion: Other agents that have been studied for the treatment of LPL deficiency are costly and have limiting side effects. Studies have shown orlistat to be safe and effective for the treatment of LPL deficiency in children. No studies have been performed in adults with LPL deficiency. Conclusion: Orlistat may be a potential adjunctive treatment option for LPL deficiency in adults, given its availability and favorable safety profile. Further research regarding orlistat in the setting of LPL deficiency is needed. |
| first_indexed | 2024-04-12T22:58:11Z |
| format | Article |
| id | doaj.art-bfc4a4edf9184cb6be254b496cbce44c |
| institution | Directory Open Access Journal |
| issn | 2376-0605 |
| language | English |
| last_indexed | 2024-04-12T22:58:11Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AACE Clinical Case Reports |
| spelling | doaj.art-bfc4a4edf9184cb6be254b496cbce44c2022-12-22T03:13:07ZengElsevierAACE Clinical Case Reports2376-06052022-03-01829395The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case ReportZachary S. Jarrett, DO0Chung-ting J. Kou, DO1WingYee Wan, MD2Jeffery A. Colburn, MD3Department of Internal Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas; Address correspondence to Dr Zachary S. Jarrett, Department of Internal Medicine, Brooke Army Medical Center, 3551 Roger Brooke Drive, JBSA Fort Sam Houston, TX 78234-4504.Department of Internal Medicine, Brooke Army Medical Center, Fort Sam Houston, TexasDepartment of Endocrinology, Brooke Army Medical Center, Fort Sam Houston, TexasDepartment of Endocrinology, Brooke Army Medical Center, Fort Sam Houston, TexasBackground: Patients with lipoprotein lipase (LPL) deficiency, an inherited disorder, develop hypertriglyceridemia, which can lead to recurrent pancreatitis. The mainstay of therapy is medical nutritional therapy. Case Report: We present the case of a 35-year-old woman with LPL deficiency who experienced recurrent hospitalizations for hypertriglyceridemia-induced pancreatitis, which was effectively treated with orlistat. Discussion: Other agents that have been studied for the treatment of LPL deficiency are costly and have limiting side effects. Studies have shown orlistat to be safe and effective for the treatment of LPL deficiency in children. No studies have been performed in adults with LPL deficiency. Conclusion: Orlistat may be a potential adjunctive treatment option for LPL deficiency in adults, given its availability and favorable safety profile. Further research regarding orlistat in the setting of LPL deficiency is needed.http://www.sciencedirect.com/science/article/pii/S237606052100122Xlipoprotein lipase deficiencyorlistathypertriglyceridemia-induced acute pancreatitis |
| spellingShingle | Zachary S. Jarrett, DO Chung-ting J. Kou, DO WingYee Wan, MD Jeffery A. Colburn, MD The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report AACE Clinical Case Reports lipoprotein lipase deficiency orlistat hypertriglyceridemia-induced acute pancreatitis |
| title | The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report |
| title_full | The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report |
| title_fullStr | The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report |
| title_full_unstemmed | The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report |
| title_short | The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report |
| title_sort | use of orlistat in an adult with lipoprotein lipase deficiency a case report |
| topic | lipoprotein lipase deficiency orlistat hypertriglyceridemia-induced acute pancreatitis |
| url | http://www.sciencedirect.com/science/article/pii/S237606052100122X |
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