Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey
Background: Recent epidemiological studies have reported an association between the ABO blood group and the acquisition, symptom severity, and mortality rate of coronavirus disease 2019 (COVID-19). However, the association between the ABO blood group antigens and the type and severity of COVID-19 va...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1006333/full |
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| author | Ohoud S. Almalki Amany S. Khalifa Ozouf F. Alhemeidi Ashraf A. Ewis Ashraf A. Ewis Abeer M. Shady Sayed F. Abdelwahab |
| author_facet | Ohoud S. Almalki Amany S. Khalifa Ozouf F. Alhemeidi Ashraf A. Ewis Ashraf A. Ewis Abeer M. Shady Sayed F. Abdelwahab |
| author_sort | Ohoud S. Almalki |
| collection | DOAJ |
| description | Background: Recent epidemiological studies have reported an association between the ABO blood group and the acquisition, symptom severity, and mortality rate of coronavirus disease 2019 (COVID-19). However, the association between the ABO blood group antigens and the type and severity of COVID-19 vaccine-related adverse reactions has not been elucidated.Patients and Methods: We conducted a cross-sectional, questionnaire-based study in Saudi Arabia from February to April 2022. The study cohort included adults who had received or were willing to receive at least two doses of a COVID-19 vaccine of any type. We used Chi-square test to assess the association between the ABO blood groups and vaccine-related adverse reactions. p values of <0.05 were considered significant.Results: Of the 1180 participants, approximately half were aged 18–30 years old, 69.2% were female, and 41.6% reported their blood group as O. The most frequent COVID-19 vaccine-related adverse reactions were fatigue (65%), pain at the injection site (56%), and headache (45.9%). These adverse reactions demonstrated significant correlations with the education level (p = 0.003) and nationality (p = 0.018) of the participants following the first dose, with gender (p < 0.001) following the second dose, and with the general health status (p < 0.001) after all the doses. Remarkably, no correlation was observed between the severity of the vaccine-related adverse reactions and ABO blood groups.Conclusion: Our findings do not support a correlation between the severity of COVID-19 vaccine-related adverse reactions and the ABO blood groups of the vaccinees. The creation of a national database is necessary to account for population differences. |
| first_indexed | 2024-04-12T05:36:02Z |
| format | Article |
| id | doaj.art-bfc6936817de4b8eb557bbc837897c95 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T05:36:02Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-bfc6936817de4b8eb557bbc837897c952022-12-22T03:45:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10063331006333Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based surveyOhoud S. Almalki0Amany S. Khalifa1Ozouf F. Alhemeidi2Ashraf A. Ewis3Ashraf A. Ewis4Abeer M. Shady5Sayed F. Abdelwahab6Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaDepartment of Pharmaceutics and Industrial pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaDepartment of Public Health, Faculty of Health Sciences-AlQunfudah, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Public Health and Occupational Medicine, Faculty of Medicine, Minia University, El-Minia, EgyptDepartment of Pharmaceutics and Industrial pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaDepartment of Pharmaceutics and Industrial pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaBackground: Recent epidemiological studies have reported an association between the ABO blood group and the acquisition, symptom severity, and mortality rate of coronavirus disease 2019 (COVID-19). However, the association between the ABO blood group antigens and the type and severity of COVID-19 vaccine-related adverse reactions has not been elucidated.Patients and Methods: We conducted a cross-sectional, questionnaire-based study in Saudi Arabia from February to April 2022. The study cohort included adults who had received or were willing to receive at least two doses of a COVID-19 vaccine of any type. We used Chi-square test to assess the association between the ABO blood groups and vaccine-related adverse reactions. p values of <0.05 were considered significant.Results: Of the 1180 participants, approximately half were aged 18–30 years old, 69.2% were female, and 41.6% reported their blood group as O. The most frequent COVID-19 vaccine-related adverse reactions were fatigue (65%), pain at the injection site (56%), and headache (45.9%). These adverse reactions demonstrated significant correlations with the education level (p = 0.003) and nationality (p = 0.018) of the participants following the first dose, with gender (p < 0.001) following the second dose, and with the general health status (p < 0.001) after all the doses. Remarkably, no correlation was observed between the severity of the vaccine-related adverse reactions and ABO blood groups.Conclusion: Our findings do not support a correlation between the severity of COVID-19 vaccine-related adverse reactions and the ABO blood groups of the vaccinees. The creation of a national database is necessary to account for population differences.https://www.frontiersin.org/articles/10.3389/fphar.2022.1006333/fullCOVID-19vaccinesseverityblood groupcommunitySaudi Arabia |
| spellingShingle | Ohoud S. Almalki Amany S. Khalifa Ozouf F. Alhemeidi Ashraf A. Ewis Ashraf A. Ewis Abeer M. Shady Sayed F. Abdelwahab Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey Frontiers in Pharmacology COVID-19 vaccines severity blood group community Saudi Arabia |
| title | Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey |
| title_full | Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey |
| title_fullStr | Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey |
| title_full_unstemmed | Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey |
| title_short | Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey |
| title_sort | correlation between the severity of covid 19 vaccine related adverse events and the blood group of the vaccinees in saudi arabia a web based survey |
| topic | COVID-19 vaccines severity blood group community Saudi Arabia |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1006333/full |
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