A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy
Alzheimer’s disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cell...
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| Format: | Article |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.614906/full |
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| author | Ying Kuang Ying Kuang Jingwen Zhang Mogao Xiong Weijia Zeng Xiaofeng Lin Xiaofeng Lin Xiaoqing Yi Yan Luo Min Yang Feng Li Qitong Huang |
| author_facet | Ying Kuang Ying Kuang Jingwen Zhang Mogao Xiong Weijia Zeng Xiaofeng Lin Xiaofeng Lin Xiaoqing Yi Yan Luo Min Yang Feng Li Qitong Huang |
| author_sort | Ying Kuang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Aβ-mediated neurotoxicity by inhibiting Aβ aggregation. However, the efficiency of targeted cellular uptake and bioavailability of CUR is very low due to its poor stability and water-solubility. In order to better improve the cell uptake efficiency and bioavailability of CUR and reduce the cytotoxicity of high-dose CUR, a novel CUR delivery system for AD therapy has been constructed based on the employment of the Fe3O4@carbon dots nanocomposite (Fe3O4@CDs) as the carrier. CUR-Fe3O4@CDs have a strong affinity toward Aβ and effectively inhibit extracellular Aβ fibrillation. In addition, CUR-Fe3O4@CDs can inhibit the production of reactive oxygen species (ROS) mediated by Aβ fibrils and the corresponding neurotoxicity in PC12 cells. More importantly, it can restore nerve damage and maintained neuronal morphology. These results indicate that the application of CUR-Fe3O4@CDs provides a promising platform for the treatment of AD. |
| first_indexed | 2024-12-13T18:46:15Z |
| format | Article |
| id | doaj.art-bfc77023b07d475e9f817b952bc02cb8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-13T18:46:15Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-bfc77023b07d475e9f817b952bc02cb82022-12-21T23:35:04ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-12-01810.3389/fbioe.2020.614906614906A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease TherapyYing Kuang0Ying Kuang1Jingwen Zhang2Mogao Xiong3Weijia Zeng4Xiaofeng Lin5Xiaofeng Lin6Xiaoqing Yi7Yan Luo8Min Yang9Feng Li10Qitong Huang11Guangdong Provincial Key Laboratory of Brain Function and Disease, Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaDepartment of Chemistry, Shantou University, Shantou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaGuangdong Provincial Key Laboratory of Brain Function and Disease, Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaOil-tea in Medical Health Care and Functional Product Development Engineering Research Center in Jiangxi, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaAlzheimer’s disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Aβ-mediated neurotoxicity by inhibiting Aβ aggregation. However, the efficiency of targeted cellular uptake and bioavailability of CUR is very low due to its poor stability and water-solubility. In order to better improve the cell uptake efficiency and bioavailability of CUR and reduce the cytotoxicity of high-dose CUR, a novel CUR delivery system for AD therapy has been constructed based on the employment of the Fe3O4@carbon dots nanocomposite (Fe3O4@CDs) as the carrier. CUR-Fe3O4@CDs have a strong affinity toward Aβ and effectively inhibit extracellular Aβ fibrillation. In addition, CUR-Fe3O4@CDs can inhibit the production of reactive oxygen species (ROS) mediated by Aβ fibrils and the corresponding neurotoxicity in PC12 cells. More importantly, it can restore nerve damage and maintained neuronal morphology. These results indicate that the application of CUR-Fe3O4@CDs provides a promising platform for the treatment of AD.https://www.frontiersin.org/articles/10.3389/fbioe.2020.614906/fullcurcuminAlzheimer’s diseaseAβ proteincarbon dotsFe3O4 nanomaterialdrug delivery |
| spellingShingle | Ying Kuang Ying Kuang Jingwen Zhang Mogao Xiong Weijia Zeng Xiaofeng Lin Xiaofeng Lin Xiaoqing Yi Yan Luo Min Yang Feng Li Qitong Huang A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy Frontiers in Bioengineering and Biotechnology curcumin Alzheimer’s disease Aβ protein carbon dots Fe3O4 nanomaterial drug delivery |
| title | A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy |
| title_full | A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy |
| title_fullStr | A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy |
| title_full_unstemmed | A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy |
| title_short | A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy |
| title_sort | novel nanosystem realizing curcumin delivery based on fe3o4 carbon dots nanocomposite for alzheimer s disease therapy |
| topic | curcumin Alzheimer’s disease Aβ protein carbon dots Fe3O4 nanomaterial drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.614906/full |
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