Infectious agent's influence on serum procalcitonin concentration in patients with sepsis
<p class="Napis2"><strong><span lang="EN-US">Abstract</span></strong></p><p class="Napis2"><strong><span lang="EN-US">Theoretical background: </span></strong><span lang="EN-US">P...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2015-04-01
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| Series: | Zdravniški Vestnik |
| Subjects: | |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/1120 |
| Summary: | <p class="Napis2"><strong><span lang="EN-US">Abstract</span></strong></p><p class="Napis2"><strong><span lang="EN-US">Theoretical background: </span></strong><span lang="EN-US">Procalcitonin (PCT) is diagnostic and prognostic biomarker of sepsis. The objective of this study was to evaluate the correlation between sepsis causative agent and serum PCT concentration, since it would influence the initial empirical antimicrobial therapy selection.<strong></strong></span></p><p class="Napis2"><strong><span lang="EN-US">Methods:</span></strong><span lang="EN-US"> This retrospective study included 96 patients with sepsis who were admitted to Intensive Care Unit of Department of Infectious Diseases and Febrile Illnesses of University Clinical Center Ljubljana from September of 2011 through March of 2013. Sepsis was established clinically and defined aetiologically by haemoculture growth. Statistical evaluation was conducted in 76 patients who had not received proper antimicrobial therapy prior to blood collection. For</span><span lang="EN-US">PCT determination imunoluminometric method was used and concentrations </span><span lang="EN-US">above 5 mg/L were considered elevated. </span><strong><span lang="EN-US">Results: </span></strong><span lang="EN-US">Serum PCT concentration was significantly higher in Gram-negative sepsis (PCT median was 26,3 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) compared to Gram-positive sepsis (PCT median was 11,2 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) (p = 0,016). Differences in PCT concentrations between Gram-positive pathogens were not statistically significant (p = 0,09), however, </span><span lang="EN-US">S. aureus</span><span lang="EN-US"> sepsis is linked to higher serum PCT concentration (</span><span lang="EN-US">median PCT 12,8 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) than all other Gram-positive agents put together </span><span lang="EN-US">(median PCT of 5,9 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> (p = 0,016). Difference in PCT concentration in </span><span lang="EN-US">E. coli</span><span lang="EN-US"> sepsis </span><span lang="EN-US">(median PCT of 38,2 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> compared to other enterobacteria </span><span lang="EN-US">(median PCT of 26,3 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> is not statistically significant (p = 0,902). </span><strong></strong></p><p class="Napis2"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> Causative agent has a significant effect on serum PCT concentration in patients with sepsis. Higher values were present in Gram-negative than in Gram-positive sepsis. Amongst Gram-positive pathogens, </span><span lang="EN-US">S. aureus</span><span lang="EN-US"> caused greater rise in PCT than other Gram-positive bacteria put together. </span></p> |
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| ISSN: | 1318-0347 1581-0224 |