Infectious agent's influence on serum procalcitonin concentration in patients with sepsis
<p class="Napis2"><strong><span lang="EN-US">Abstract</span></strong></p><p class="Napis2"><strong><span lang="EN-US">Theoretical background: </span></strong><span lang="EN-US">P...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2015-04-01
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| Series: | Zdravniški Vestnik |
| Subjects: | |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/1120 |
| _version_ | 1811233900129681408 |
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| author | Sara Jereb Natalija Planinc Strunjaš Matjaž Jereb |
| author_facet | Sara Jereb Natalija Planinc Strunjaš Matjaž Jereb |
| author_sort | Sara Jereb |
| collection | DOAJ |
| description | <p class="Napis2"><strong><span lang="EN-US">Abstract</span></strong></p><p class="Napis2"><strong><span lang="EN-US">Theoretical background: </span></strong><span lang="EN-US">Procalcitonin (PCT) is diagnostic and prognostic biomarker of sepsis. The objective of this study was to evaluate the correlation between sepsis causative agent and serum PCT concentration, since it would influence the initial empirical antimicrobial therapy selection.<strong></strong></span></p><p class="Napis2"><strong><span lang="EN-US">Methods:</span></strong><span lang="EN-US"> This retrospective study included 96 patients with sepsis who were admitted to Intensive Care Unit of Department of Infectious Diseases and Febrile Illnesses of University Clinical Center Ljubljana from September of 2011 through March of 2013. Sepsis was established clinically and defined aetiologically by haemoculture growth. Statistical evaluation was conducted in 76 patients who had not received proper antimicrobial therapy prior to blood collection. For</span><span lang="EN-US">PCT determination imunoluminometric method was used and concentrations </span><span lang="EN-US">above 5 mg/L were considered elevated. </span><strong><span lang="EN-US">Results: </span></strong><span lang="EN-US">Serum PCT concentration was significantly higher in Gram-negative sepsis (PCT median was 26,3 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) compared to Gram-positive sepsis (PCT median was 11,2 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) (p = 0,016). Differences in PCT concentrations between Gram-positive pathogens were not statistically significant (p = 0,09), however, </span><span lang="EN-US">S. aureus</span><span lang="EN-US"> sepsis is linked to higher serum PCT concentration (</span><span lang="EN-US">median PCT 12,8 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) than all other Gram-positive agents put together </span><span lang="EN-US">(median PCT of 5,9 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> (p = 0,016). Difference in PCT concentration in </span><span lang="EN-US">E. coli</span><span lang="EN-US"> sepsis </span><span lang="EN-US">(median PCT of 38,2 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> compared to other enterobacteria </span><span lang="EN-US">(median PCT of 26,3 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> is not statistically significant (p = 0,902). </span><strong></strong></p><p class="Napis2"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> Causative agent has a significant effect on serum PCT concentration in patients with sepsis. Higher values were present in Gram-negative than in Gram-positive sepsis. Amongst Gram-positive pathogens, </span><span lang="EN-US">S. aureus</span><span lang="EN-US"> caused greater rise in PCT than other Gram-positive bacteria put together. </span></p> |
| first_indexed | 2024-04-12T11:27:48Z |
| format | Article |
| id | doaj.art-bfc956f23b26475084616878fa51bdff |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-04-12T11:27:48Z |
| publishDate | 2015-04-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-bfc956f23b26475084616878fa51bdff2022-12-22T03:35:11ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242015-04-01842980Infectious agent's influence on serum procalcitonin concentration in patients with sepsisSara Jereb0Natalija Planinc Strunjaš1Matjaž Jereb2Infectious Diseases Department, University Medical Center LjubljanaInfectious Diseases Department, University Medical Center LjubljanaInfectious Diseases Department, University Medical Center Ljubljana<p class="Napis2"><strong><span lang="EN-US">Abstract</span></strong></p><p class="Napis2"><strong><span lang="EN-US">Theoretical background: </span></strong><span lang="EN-US">Procalcitonin (PCT) is diagnostic and prognostic biomarker of sepsis. The objective of this study was to evaluate the correlation between sepsis causative agent and serum PCT concentration, since it would influence the initial empirical antimicrobial therapy selection.<strong></strong></span></p><p class="Napis2"><strong><span lang="EN-US">Methods:</span></strong><span lang="EN-US"> This retrospective study included 96 patients with sepsis who were admitted to Intensive Care Unit of Department of Infectious Diseases and Febrile Illnesses of University Clinical Center Ljubljana from September of 2011 through March of 2013. Sepsis was established clinically and defined aetiologically by haemoculture growth. Statistical evaluation was conducted in 76 patients who had not received proper antimicrobial therapy prior to blood collection. For</span><span lang="EN-US">PCT determination imunoluminometric method was used and concentrations </span><span lang="EN-US">above 5 mg/L were considered elevated. </span><strong><span lang="EN-US">Results: </span></strong><span lang="EN-US">Serum PCT concentration was significantly higher in Gram-negative sepsis (PCT median was 26,3 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) compared to Gram-positive sepsis (PCT median was 11,2 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) (p = 0,016). Differences in PCT concentrations between Gram-positive pathogens were not statistically significant (p = 0,09), however, </span><span lang="EN-US">S. aureus</span><span lang="EN-US"> sepsis is linked to higher serum PCT concentration (</span><span lang="EN-US">median PCT 12,8 </span><span lang="EN-US">μg/L</span><span lang="EN-US">) than all other Gram-positive agents put together </span><span lang="EN-US">(median PCT of 5,9 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> (p = 0,016). Difference in PCT concentration in </span><span lang="EN-US">E. coli</span><span lang="EN-US"> sepsis </span><span lang="EN-US">(median PCT of 38,2 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> compared to other enterobacteria </span><span lang="EN-US">(median PCT of 26,3 </span><span lang="EN-US">μg/L</span><span lang="EN-US">)</span><span lang="EN-US"> is not statistically significant (p = 0,902). </span><strong></strong></p><p class="Napis2"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> Causative agent has a significant effect on serum PCT concentration in patients with sepsis. Higher values were present in Gram-negative than in Gram-positive sepsis. Amongst Gram-positive pathogens, </span><span lang="EN-US">S. aureus</span><span lang="EN-US"> caused greater rise in PCT than other Gram-positive bacteria put together. </span></p>http://vestnik.szd.si/index.php/ZdravVest/article/view/1120procalcitonin, sepsis, causative agent, aetiology, correlation |
| spellingShingle | Sara Jereb Natalija Planinc Strunjaš Matjaž Jereb Infectious agent's influence on serum procalcitonin concentration in patients with sepsis Zdravniški Vestnik procalcitonin, sepsis, causative agent, aetiology, correlation |
| title | Infectious agent's influence on serum procalcitonin concentration in patients with sepsis |
| title_full | Infectious agent's influence on serum procalcitonin concentration in patients with sepsis |
| title_fullStr | Infectious agent's influence on serum procalcitonin concentration in patients with sepsis |
| title_full_unstemmed | Infectious agent's influence on serum procalcitonin concentration in patients with sepsis |
| title_short | Infectious agent's influence on serum procalcitonin concentration in patients with sepsis |
| title_sort | infectious agent s influence on serum procalcitonin concentration in patients with sepsis |
| topic | procalcitonin, sepsis, causative agent, aetiology, correlation |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/1120 |
| work_keys_str_mv | AT sarajereb infectiousagentsinfluenceonserumprocalcitoninconcentrationinpatientswithsepsis AT natalijaplanincstrunjas infectiousagentsinfluenceonserumprocalcitoninconcentrationinpatientswithsepsis AT matjazjereb infectiousagentsinfluenceonserumprocalcitoninconcentrationinpatientswithsepsis |