Role of rosuvastatin in bone metabolism of ovariectomized adult rats
The study was planned to explore the influence of one type of hydrophilic statins (rosuvastatin) on the level of serum osteocalcin, N-telopeptide of type 1 collagen (NTx), calcium, and phosphorus. In addition to calcium, phosphorus, and magnesium in femur bone ash of female ovariectomized rats. Thir...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2023-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
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| Online Access: | https://www.vetmedmosul.com/article_176551_83427427ecd76b0f85d26e0ebe6ba79e.pdf |
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| author | Sumaya S. Salih Elham M. Al-Khashab |
| author_facet | Sumaya S. Salih Elham M. Al-Khashab |
| author_sort | Sumaya S. Salih |
| collection | DOAJ |
| description | The study was planned to explore the influence of one type of hydrophilic statins (rosuvastatin) on the level of serum osteocalcin, N-telopeptide of type 1 collagen (NTx), calcium, and phosphorus. In addition to calcium, phosphorus, and magnesium in femur bone ash of female ovariectomized rats. Thirty female rats aged 2.5-3 months were divided as follows, sham group, ovariectomized (ovx) group as a model of osteoporosis, and (ovx) group treated with 20mg /kg of rosuvastatin for 60 days. Blood samples were collected after 30 and 60 days of the experiment for biochemical analysis. Besides, after 60 days of the treatment, right femur bones were excised and ashed to estimate calcium, phosphorus, and magnesium. The results showed a significant elevation in serum osteocalcin, (NTx), calcium, and phosphorus, in addition to elevation in osteoclasts number and deceased osteoblasts and thickness of trabecular bone in the (ovx) group compared to the sham, while treatment with rosuvastatin caused a significant reduction in osteocalcin, (NTx), calcium and phosphorus after 60 days. Also, the results revealed a significant reduction in the percentage of (Ca, P and Mg) content in bone ash of the (ovx) group compared to the sham group. However, rosuvastatin treatment led to a significant elevation in the percentage of calcium and inorganic phosphate in bone ash and increased the thickness of trabecular bone and development in osteocytes compared with ovariectomized rats. The conclusion of the present study, rosuvastatin has a positive effect on the bone of ovariectomized rats. |
| first_indexed | 2024-04-11T04:40:31Z |
| format | Article |
| id | doaj.art-bfca850dd9a3447f9949acaee4d9c243 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-04-11T04:40:31Z |
| publishDate | 2023-01-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-bfca850dd9a3447f9949acaee4d9c2432022-12-28T06:28:35ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552023-01-0137126727310.33899/ijvs.2022.133840.2309176551Role of rosuvastatin in bone metabolism of ovariectomized adult ratsSumaya S. Salih0Elham M. Al-Khashab1Department of Physiology, Biochemistry, and Pharmacology, Collage of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqThe study was planned to explore the influence of one type of hydrophilic statins (rosuvastatin) on the level of serum osteocalcin, N-telopeptide of type 1 collagen (NTx), calcium, and phosphorus. In addition to calcium, phosphorus, and magnesium in femur bone ash of female ovariectomized rats. Thirty female rats aged 2.5-3 months were divided as follows, sham group, ovariectomized (ovx) group as a model of osteoporosis, and (ovx) group treated with 20mg /kg of rosuvastatin for 60 days. Blood samples were collected after 30 and 60 days of the experiment for biochemical analysis. Besides, after 60 days of the treatment, right femur bones were excised and ashed to estimate calcium, phosphorus, and magnesium. The results showed a significant elevation in serum osteocalcin, (NTx), calcium, and phosphorus, in addition to elevation in osteoclasts number and deceased osteoblasts and thickness of trabecular bone in the (ovx) group compared to the sham, while treatment with rosuvastatin caused a significant reduction in osteocalcin, (NTx), calcium and phosphorus after 60 days. Also, the results revealed a significant reduction in the percentage of (Ca, P and Mg) content in bone ash of the (ovx) group compared to the sham group. However, rosuvastatin treatment led to a significant elevation in the percentage of calcium and inorganic phosphate in bone ash and increased the thickness of trabecular bone and development in osteocytes compared with ovariectomized rats. The conclusion of the present study, rosuvastatin has a positive effect on the bone of ovariectomized rats.https://www.vetmedmosul.com/article_176551_83427427ecd76b0f85d26e0ebe6ba79e.pdfntxosteocalcinovariectomized ratsrosuvastatin |
| spellingShingle | Sumaya S. Salih Elham M. Al-Khashab Role of rosuvastatin in bone metabolism of ovariectomized adult rats Iraqi Journal of Veterinary Sciences ntx osteocalcin ovariectomized rats rosuvastatin |
| title | Role of rosuvastatin in bone metabolism of ovariectomized adult rats |
| title_full | Role of rosuvastatin in bone metabolism of ovariectomized adult rats |
| title_fullStr | Role of rosuvastatin in bone metabolism of ovariectomized adult rats |
| title_full_unstemmed | Role of rosuvastatin in bone metabolism of ovariectomized adult rats |
| title_short | Role of rosuvastatin in bone metabolism of ovariectomized adult rats |
| title_sort | role of rosuvastatin in bone metabolism of ovariectomized adult rats |
| topic | ntx osteocalcin ovariectomized rats rosuvastatin |
| url | https://www.vetmedmosul.com/article_176551_83427427ecd76b0f85d26e0ebe6ba79e.pdf |
| work_keys_str_mv | AT sumayassalih roleofrosuvastatininbonemetabolismofovariectomizedadultrats AT elhammalkhashab roleofrosuvastatininbonemetabolismofovariectomizedadultrats |