Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids
<i>Background</i>: Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and correlated with poor prognosis. The aim of this study was to a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/4/797 |
| _version_ | 1797436159589089280 |
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| author | Brian C. DeFelice Oliver Fiehn Peter Belafsky Constanze Ditterich Michael Moore Marianne Abouyared Angela M. Beliveau D. Gregory Farwell Arnaud F. Bewley Shannon M. Clayton Joehleen A. Archard Jordan Pavlic Shyam Rao Maggie Kuhn Peter Deng Julian Halmai Kyle D. Fink Andrew C. Birkeland Johnathon D. Anderson |
| author_facet | Brian C. DeFelice Oliver Fiehn Peter Belafsky Constanze Ditterich Michael Moore Marianne Abouyared Angela M. Beliveau D. Gregory Farwell Arnaud F. Bewley Shannon M. Clayton Joehleen A. Archard Jordan Pavlic Shyam Rao Maggie Kuhn Peter Deng Julian Halmai Kyle D. Fink Andrew C. Birkeland Johnathon D. Anderson |
| author_sort | Brian C. DeFelice |
| collection | DOAJ |
| description | <i>Background</i>: Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and correlated with poor prognosis. The aim of this study was to assess the concentration of polyamines in the saliva and urine from head and neck cancer (HNC) patients, compared to healthy controls. <i>Methods:</i> Targeted metabolomic analysis was performed on saliva and urine from 39 HNC patient samples and compared to 89 healthy controls using a quantitative, targeted liquid chromatography mass spectrometry approach. <i>Results:</i> The metabolites N<sup>1</sup>-acetylspermine (ASP), N<sup>8</sup>-acetylspermidine (ASD) and N<sup>1</sup>,N<sup>12</sup>-diacetylspermine (DAS) were detected at significantly different concentrations in the urine of HNC patients as compared to healthy controls. Only ASP was detected at elevated levels in HNC saliva as compared to healthy controls. <i>Conclusion:</i> These data suggest that assessment of polyamine-based metabolite biomarkers within the saliva and urine warrants further investigation as a potential diagnostic in HNC patients. |
| first_indexed | 2024-03-09T10:58:32Z |
| format | Article |
| id | doaj.art-bfcb0005f6684b4da7b98da07248dadf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T10:58:32Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bfcb0005f6684b4da7b98da07248dadf2023-12-01T01:29:37ZengMDPI AGDiagnostics2075-44182022-03-0112479710.3390/diagnostics12040797Polyamine Metabolites as Biomarkers in Head and Neck Cancer BiofluidsBrian C. DeFelice0Oliver Fiehn1Peter Belafsky2Constanze Ditterich3Michael Moore4Marianne Abouyared5Angela M. Beliveau6D. Gregory Farwell7Arnaud F. Bewley8Shannon M. Clayton9Joehleen A. Archard10Jordan Pavlic11Shyam Rao12Maggie Kuhn13Peter Deng14Julian Halmai15Kyle D. Fink16Andrew C. Birkeland17Johnathon D. Anderson18West Coast Metabolomics Center, University of California, Davis, CA 95616, USAWest Coast Metabolomics Center, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Radiation Oncology, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Neurology, University of California, Davis, CA 95616, USADepartment of Neurology, University of California, Davis, CA 95616, USADepartment of Neurology, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USADepartment of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA<i>Background</i>: Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and correlated with poor prognosis. The aim of this study was to assess the concentration of polyamines in the saliva and urine from head and neck cancer (HNC) patients, compared to healthy controls. <i>Methods:</i> Targeted metabolomic analysis was performed on saliva and urine from 39 HNC patient samples and compared to 89 healthy controls using a quantitative, targeted liquid chromatography mass spectrometry approach. <i>Results:</i> The metabolites N<sup>1</sup>-acetylspermine (ASP), N<sup>8</sup>-acetylspermidine (ASD) and N<sup>1</sup>,N<sup>12</sup>-diacetylspermine (DAS) were detected at significantly different concentrations in the urine of HNC patients as compared to healthy controls. Only ASP was detected at elevated levels in HNC saliva as compared to healthy controls. <i>Conclusion:</i> These data suggest that assessment of polyamine-based metabolite biomarkers within the saliva and urine warrants further investigation as a potential diagnostic in HNC patients.https://www.mdpi.com/2075-4418/12/4/797head and neck cancerbiomarkersmetabolomicspolyaminessalivaurine |
| spellingShingle | Brian C. DeFelice Oliver Fiehn Peter Belafsky Constanze Ditterich Michael Moore Marianne Abouyared Angela M. Beliveau D. Gregory Farwell Arnaud F. Bewley Shannon M. Clayton Joehleen A. Archard Jordan Pavlic Shyam Rao Maggie Kuhn Peter Deng Julian Halmai Kyle D. Fink Andrew C. Birkeland Johnathon D. Anderson Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids Diagnostics head and neck cancer biomarkers metabolomics polyamines saliva urine |
| title | Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids |
| title_full | Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids |
| title_fullStr | Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids |
| title_full_unstemmed | Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids |
| title_short | Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids |
| title_sort | polyamine metabolites as biomarkers in head and neck cancer biofluids |
| topic | head and neck cancer biomarkers metabolomics polyamines saliva urine |
| url | https://www.mdpi.com/2075-4418/12/4/797 |
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