A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation
A 38-year-old man with a diagnosis of BRAF-mutated metastatic melanoma was referred to our clinic. He had been under treatment with 60-mg oral cobimetinib daily for 21 days/7 day off in combination with 960 mg vemurafenib twice daily. The patient had symptoms of blurred vision and photophobia in his...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=2073;epage=2075;aulast=Asfuroglu |
| _version_ | 1819063776827146240 |
|---|---|
| author | Mahmut Asfuroglu Yonca Asfuroğlu |
| author_facet | Mahmut Asfuroglu Yonca Asfuroğlu |
| author_sort | Mahmut Asfuroglu |
| collection | DOAJ |
| description | A 38-year-old man with a diagnosis of BRAF-mutated metastatic melanoma was referred to our clinic. He had been under treatment with 60-mg oral cobimetinib daily for 21 days/7 day off in combination with 960 mg vemurafenib twice daily. The patient had symptoms of blurred vision and photophobia in his right eye. A slit-lamp examination revealed bilateral central corneal stromal opacity and epithelial microcystic edema Involvement was more severe in the right eye compared with the left eye. Fourteen days after the first visit, the patient's symptoms and slit-lamp findings were largely resolved. We suggest that endothelium pump failure was involved in this acute corneal decompensation case similar to the mechanism in retinal pigment epithelium. |
| first_indexed | 2024-12-21T15:20:03Z |
| format | Article |
| id | doaj.art-bfcb2966493242f7a32db1ec620cb7e9 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-21T15:20:03Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-bfcb2966493242f7a32db1ec620cb7e92022-12-21T18:59:03ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892019-01-0167122073207510.4103/ijo.IJO_2025_18A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensationMahmut AsfurogluYonca AsfuroğluA 38-year-old man with a diagnosis of BRAF-mutated metastatic melanoma was referred to our clinic. He had been under treatment with 60-mg oral cobimetinib daily for 21 days/7 day off in combination with 960 mg vemurafenib twice daily. The patient had symptoms of blurred vision and photophobia in his right eye. A slit-lamp examination revealed bilateral central corneal stromal opacity and epithelial microcystic edema Involvement was more severe in the right eye compared with the left eye. Fourteen days after the first visit, the patient's symptoms and slit-lamp findings were largely resolved. We suggest that endothelium pump failure was involved in this acute corneal decompensation case similar to the mechanism in retinal pigment epithelium.http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=2073;epage=2075;aulast=Asfuroglucorneal decompensationcobimetinibmek inhibitor |
| spellingShingle | Mahmut Asfuroglu Yonca Asfuroğlu A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation Indian Journal of Ophthalmology corneal decompensation cobimetinib mek inhibitor |
| title | A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation |
| title_full | A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation |
| title_fullStr | A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation |
| title_full_unstemmed | A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation |
| title_short | A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation |
| title_sort | novel side effect of mitogen activated protein kinase inhibitor cobimetinib acute corneal decompensation |
| topic | corneal decompensation cobimetinib mek inhibitor |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=2073;epage=2075;aulast=Asfuroglu |
| work_keys_str_mv | AT mahmutasfuroglu anovelsideeffectofmitogenactivatedproteinkinaseinhibitorcobimetinibacutecornealdecompensation AT yoncaasfuroglu anovelsideeffectofmitogenactivatedproteinkinaseinhibitorcobimetinibacutecornealdecompensation AT mahmutasfuroglu novelsideeffectofmitogenactivatedproteinkinaseinhibitorcobimetinibacutecornealdecompensation AT yoncaasfuroglu novelsideeffectofmitogenactivatedproteinkinaseinhibitorcobimetinibacutecornealdecompensation |