Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta-cells in the pancreas, caused by the interplay of genetic and environmental factors. Despite the introduction of advanced technologies for diabetes management, most patients fail to achieve target glycemic control, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/2805 |
| _version_ | 1797555138507833344 |
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| author | Przemysław Beik Martyna Ciesielska Maria Kucza Alicja Kurczewska Joanna Kuźmińska Bartosz Maćkowiak Elżbieta Niechciał |
| author_facet | Przemysław Beik Martyna Ciesielska Maria Kucza Alicja Kurczewska Joanna Kuźmińska Bartosz Maćkowiak Elżbieta Niechciał |
| author_sort | Przemysław Beik |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta-cells in the pancreas, caused by the interplay of genetic and environmental factors. Despite the introduction of advanced technologies for diabetes management, most patients fail to achieve target glycemic control, and T1D still has a high burden of long-term end-organ complications. Over several decades, multiple clinical trials have attempted to find prevention for T1D in at-risk individuals or to stabilize, ultimately reverse, the disease in those with T1D. To date, T1D remains yet incurable condition; however, recently improved understanding of the natural history of the disease may lead to new strategies to preserve or improve beta-cell function in those at increased risk and T1D patients. This publication aims to provide an overview of past experiences and recent findings in the prevention of T1D. |
| first_indexed | 2024-03-10T16:42:18Z |
| format | Article |
| id | doaj.art-bfcb3c8332d3459e885b74ba611f592e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:42:18Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bfcb3c8332d3459e885b74ba611f592e2023-11-20T11:55:46ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0199280510.3390/jcm9092805Prevention of Type 1 Diabetes: Past Experiences and Future OpportunitiesPrzemysław Beik0Martyna Ciesielska1Maria Kucza2Alicja Kurczewska3Joanna Kuźmińska4Bartosz Maćkowiak5Elżbieta Niechciał6Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, PolandType 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta-cells in the pancreas, caused by the interplay of genetic and environmental factors. Despite the introduction of advanced technologies for diabetes management, most patients fail to achieve target glycemic control, and T1D still has a high burden of long-term end-organ complications. Over several decades, multiple clinical trials have attempted to find prevention for T1D in at-risk individuals or to stabilize, ultimately reverse, the disease in those with T1D. To date, T1D remains yet incurable condition; however, recently improved understanding of the natural history of the disease may lead to new strategies to preserve or improve beta-cell function in those at increased risk and T1D patients. This publication aims to provide an overview of past experiences and recent findings in the prevention of T1D.https://www.mdpi.com/2077-0383/9/9/2805type 1 diabetesautoimmune diseasespreventionbeta-cell functionclinical trials |
| spellingShingle | Przemysław Beik Martyna Ciesielska Maria Kucza Alicja Kurczewska Joanna Kuźmińska Bartosz Maćkowiak Elżbieta Niechciał Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities Journal of Clinical Medicine type 1 diabetes autoimmune diseases prevention beta-cell function clinical trials |
| title | Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities |
| title_full | Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities |
| title_fullStr | Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities |
| title_full_unstemmed | Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities |
| title_short | Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities |
| title_sort | prevention of type 1 diabetes past experiences and future opportunities |
| topic | type 1 diabetes autoimmune diseases prevention beta-cell function clinical trials |
| url | https://www.mdpi.com/2077-0383/9/9/2805 |
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