Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)
Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural en...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1594862 |
| _version_ | 1817981484577849344 |
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| author | Lei Wang Jianwei Xu Ye Yan Han Liu Thiruventhan Karunakaran Feng Li |
| author_facet | Lei Wang Jianwei Xu Ye Yan Han Liu Thiruventhan Karunakaran Feng Li |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. Scutellaria barbata species was used majorly as food or as medicines against various diseases, and extensive research was conducted for their therapeutic properties. The present research was mainly focused on the synthesis of gold nanoparticles from the Scutellaria barbata by green route method and evaluation of its anticancer activity against pancreatic cancer cell lines (PANC-1). The gold nanoparticles have been characterized by UV–visible spectroscopy, TEM, SAED, AFM, and FTIR analysis. The synthesized gold nanoparticles (AuNPs) possessed effective anticancer activity against pancreatic cancer cell lines (PANC-1). Hence, further research on this plant may lead to the development of novel anticancer drugs which can be used to combat pancreatic cancer. |
| first_indexed | 2024-04-13T23:06:35Z |
| format | Article |
| id | doaj.art-bfd17932ea7248eb9d55eef63b98ec0b |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-04-13T23:06:35Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-bfd17932ea7248eb9d55eef63b98ec0b2022-12-22T02:25:40ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014711617162710.1080/21691401.2019.1594862Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)Lei Wang0Jianwei Xu1Ye Yan2Han Liu3Thiruventhan Karunakaran4Feng Li5Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, ChinaDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, ChinaDepartment of Ultrasound and Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, ChinaDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, ChinaCentre For Drug Research, Universiti Sains Malaysia, Pulau Pinang, MalaysiaDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, ChinaNanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. Scutellaria barbata species was used majorly as food or as medicines against various diseases, and extensive research was conducted for their therapeutic properties. The present research was mainly focused on the synthesis of gold nanoparticles from the Scutellaria barbata by green route method and evaluation of its anticancer activity against pancreatic cancer cell lines (PANC-1). The gold nanoparticles have been characterized by UV–visible spectroscopy, TEM, SAED, AFM, and FTIR analysis. The synthesized gold nanoparticles (AuNPs) possessed effective anticancer activity against pancreatic cancer cell lines (PANC-1). Hence, further research on this plant may lead to the development of novel anticancer drugs which can be used to combat pancreatic cancer.https://www.tandfonline.com/doi/10.1080/21691401.2019.1594862Scutellaria barbatapancreatic cancergold nanoparticlesMTT cytotoxicity assayapoptosisRT-PCR and western blotting |
| spellingShingle | Lei Wang Jianwei Xu Ye Yan Han Liu Thiruventhan Karunakaran Feng Li Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1) Artificial Cells, Nanomedicine, and Biotechnology Scutellaria barbata pancreatic cancer gold nanoparticles MTT cytotoxicity assay apoptosis RT-PCR and western blotting |
| title | Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1) |
| title_full | Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1) |
| title_fullStr | Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1) |
| title_full_unstemmed | Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1) |
| title_short | Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1) |
| title_sort | green synthesis of gold nanoparticles from scutellaria barbata and its anticancer activity in pancreatic cancer cell panc 1 |
| topic | Scutellaria barbata pancreatic cancer gold nanoparticles MTT cytotoxicity assay apoptosis RT-PCR and western blotting |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1594862 |
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