Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the sur...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2010-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007 |
| _version_ | 1827880876009062400 |
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| author | Joyce Thornhill John Kusel Fabricia Alvisi de Oliviera Fabio Ribeiro Symone Fulgêncio Lima Paulo Marcos Zech Coelho Paul McVeigh Ana Carolina Alves Mattos |
| author_facet | Joyce Thornhill John Kusel Fabricia Alvisi de Oliviera Fabio Ribeiro Symone Fulgêncio Lima Paulo Marcos Zech Coelho Paul McVeigh Ana Carolina Alves Mattos |
| author_sort | Joyce Thornhill |
| collection | DOAJ |
| description | Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum. |
| first_indexed | 2024-03-12T18:30:16Z |
| format | Article |
| id | doaj.art-bfd353ce25ee4aebae07518254ff0746 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:30:16Z |
| publishDate | 2010-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-bfd353ce25ee4aebae07518254ff07462023-08-02T08:19:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-07-01105438739010.1590/S0074-02762010000400007Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)Joyce ThornhillJohn KuselFabricia Alvisi de OlivieraFabio RibeiroSymone Fulgêncio LimaPaulo Marcos Zech CoelhoPaul McVeighAna Carolina Alves MattosHere, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007Schistosoma mansonimembrane impermeant Lucifer Yellownephridioporehostlinoleic acid |
| spellingShingle | Joyce Thornhill John Kusel Fabricia Alvisi de Oliviera Fabio Ribeiro Symone Fulgêncio Lima Paulo Marcos Zech Coelho Paul McVeigh Ana Carolina Alves Mattos Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) Memorias do Instituto Oswaldo Cruz Schistosoma mansoni membrane impermeant Lucifer Yellow nephridiopore host linoleic acid |
| title | Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) |
| title_full | Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) |
| title_fullStr | Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) |
| title_full_unstemmed | Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) |
| title_short | Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) |
| title_sort | uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula schistosoma mansoni |
| topic | Schistosoma mansoni membrane impermeant Lucifer Yellow nephridiopore host linoleic acid |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007 |
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