Epitranscriptome and FMRP Regulated mRNA Translation
An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modificati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Epigenomes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4655/1/2/11 |
| _version_ | 1797761864459878400 |
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| author | Pritha Majumder Biswanath Chatterjee C.-K. James Shen |
| author_facet | Pritha Majumder Biswanath Chatterjee C.-K. James Shen |
| author_sort | Pritha Majumder |
| collection | DOAJ |
| description | An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP). |
| first_indexed | 2024-03-12T19:19:16Z |
| format | Article |
| id | doaj.art-bfd3db55e5704da0ba16a259f7671ed6 |
| institution | Directory Open Access Journal |
| issn | 2075-4655 |
| language | English |
| last_indexed | 2024-03-12T19:19:16Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj.art-bfd3db55e5704da0ba16a259f7671ed62023-08-02T05:20:02ZengMDPI AGEpigenomes2075-46552017-07-01121110.3390/epigenomes1020011epigenomes1020011Epitranscriptome and FMRP Regulated mRNA TranslationPritha Majumder0Biswanath Chatterjee1C.-K. James Shen2Institute of Molecular Biology, Academia Sinica, Taipei 115, TaiwanInstitute of Molecular Biology, Academia Sinica, Taipei 115, TaiwanInstitute of Molecular Biology, Academia Sinica, Taipei 115, TaiwanAn important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).https://www.mdpi.com/2075-4655/1/2/11epitranscriptomeFMRPTDP-43RNA methylationRNA editingdendritic local translationneurological diseases |
| spellingShingle | Pritha Majumder Biswanath Chatterjee C.-K. James Shen Epitranscriptome and FMRP Regulated mRNA Translation Epigenomes epitranscriptome FMRP TDP-43 RNA methylation RNA editing dendritic local translation neurological diseases |
| title | Epitranscriptome and FMRP Regulated mRNA Translation |
| title_full | Epitranscriptome and FMRP Regulated mRNA Translation |
| title_fullStr | Epitranscriptome and FMRP Regulated mRNA Translation |
| title_full_unstemmed | Epitranscriptome and FMRP Regulated mRNA Translation |
| title_short | Epitranscriptome and FMRP Regulated mRNA Translation |
| title_sort | epitranscriptome and fmrp regulated mrna translation |
| topic | epitranscriptome FMRP TDP-43 RNA methylation RNA editing dendritic local translation neurological diseases |
| url | https://www.mdpi.com/2075-4655/1/2/11 |
| work_keys_str_mv | AT prithamajumder epitranscriptomeandfmrpregulatedmrnatranslation AT biswanathchatterjee epitranscriptomeandfmrpregulatedmrnatranslation AT ckjamesshen epitranscriptomeandfmrpregulatedmrnatranslation |